Results 91 to 100 of about 6,455,829 (284)
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
GelsThe regeneration of bone and the repair of large segmental bone defects represent critical challenges in regenerative medicine. Natural bone tissue is an anisotropic material characterized by an intricate gradient distribution in structure, mechanical ...
Haitao Liu +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
On 'spot' evolution under an adverse pressure gradient [PDF]
, 2001 The unsteady travelling 'spots' or spot-like disturbances are produced, in an otherwise planar boundary layer, by an initial impulse/blip, from wall forcing or from nearby external forcing. Theory and computations are described for the evolving spot-like
Timoshin, SN, Smith, FT
core
Rprop Using the Natural Gradient
, 2005 Gradient-based optimization algorithms are the standard methods for adapting the weights of neural networks. The natural gradient gives the steepest descent direction based on a non-Euclidean, from a theoretical point of view more appropriate metric in ...
Wan Weishui +2 more
core +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Computationally efficient natural gradient descent [PDF]
This study examines the use of matrix momentum terms with the aim of creating a more computationally efficient natural gradient descent algorithm for on-line learning.
Farmer, Sara-Jayne
core +1 more source
Natural gradient algorithm for cyclostationary sources
, 2002 A new approach to blind source separation of cyclostationary sources is introduced which incorporates a cyclic pre-whitening operation within the learning rule, and thereby provides a new member of the family of natural gradient algorithms. The technique
M.G. Jafari +5 more
core +2 more sources
A continuous/discontinuous Galerkin formulation for a strain gradient-dependent damage model [PDF]
, 2003 The numerical solution of strain gradient-dependent continuum problems has been hindered by continuity demands on the basis functions. The presence of terms in constitutive models that involve gradients of the strain field means that the $C^0$ continuity
G. N. Wells +5 more
core +5 more sources