Results 71 to 80 of about 580,652 (288)
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Rprop Using the Natural Gradient
, 2005 Gradient-based optimization algorithms are the standard methods for adapting the weights of neural networks. The natural gradient gives the steepest descent direction based on a non-Euclidean, from a theoretical point of view more appropriate metric in ...
Wan Weishui +2 more
core +1 more source
Natural Conjugate Gradient in Variational Inference [PDF]
, 2008 Variational methods for approximate inference in machine learning often adapt a parametric probability distribution to optimize a given objective function. This view is especially useful when applying variational Bayes (VB) to models outside the conjugate-exponential family. For them, variational Bayesian expectation maximization (VB EM) algorithms are
Antti Honkela +3 more
openaire +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Variable-step blind source separation method with adaptive momentum factor
Tongxin xuebao, 2017 A variable-step blind source separation algorithm based on the natural gradient with adaptive momentum factor was proposed,which could cope with the determined blind source separation in the environment of stationary and non-stationary.Function ...
Tian-qi ZHANG +3 more
doaj
Invariance properties of the natural gradient in overparametrised systems
, 2023 The natural gradient field is a vector field that lives on a model equipped with a distinguished Riemannian metric, e.g. the Fisher–Rao metric, and represents the direction of steepest ascent of an objective function on the model with respect to this ...
Müller, Johannes +2 more
core +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Vadose Zone Journal, 2022 Clay content in soil potentially has strong influence on soil structure and thereby controls soil physical, hydraulic, and gas transport properties. Only few studies have investigated the effect of clay content on saturated hydraulic conductivity (Ks ...
Ting Yang +5 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source