Results 81 to 90 of about 88,297 (298)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Visual comparison and exploration of natural history collections [PDF]
Proceedings of the working conference on Advanced visual interfaces - AVI '06, 2006 Natural history museum collections contain a wealth of specimen level data that is now opening up for digital access. However, current interfaces to access and manipulate this data are standard text-based query mechanisms, giving no leeway for exploratory investigation of the collections. By adapting previous work on multiple taxonomies we allow visual
Martin Graham 0001 +2 more
openaire +1 more source
University museums and collections of natural history [PDF]
, 2005 Natural history museums and collections at American universities have been in decline for the past 30 years, due in part to increasing constraints on the financial support framework and the perception that natural history museums may be no longer central
Hutterer, Karl L.
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
One World Collection: The state of the world’s natural history collections [PDF]
Biodiversity Information Science and Standards, 2019 The world's natural history collections represent a vast repository of information on the natural and cultural world, collected over 250 years of human exploration, and distributed across institutions on six continents. These collections provide a unique tool for answering fundamental questions about biological, geological and cultural diversity and ...
Owens,Ian, Johnson,Kirk
openaire +2 more sources
The Clements Site (41CS25) : a late 17th- to early 18th-century Nasoni Caddo settlement and cemetery. (Anthropological papers of the American Museum of Natural History, no. 92) [PDF]
, 2010 52 p. : ill., maps ; 26 cm. "Issued February 16, 2010." Includes bibliographical references (p. 47-52).The Clements site (41CS25) is a late 17th- to early 18th-century Nasoni Caddo settlement and cemetery on Black Bayou in the northeastern Texas ...
Nelson, Bo. +5 more
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source