Results 31 to 40 of about 22,064,156 (269)
Bulletin of the Mineral Research and ExplorationIn this study, Early Miocene bivalve fauna obtained from Hekimhan Aksütlü locality is presented. Abundant and well-preserved ostreid samples are interesting in the area where molluscs have notbeen studied before.
Müjde Gürsoy
doaj +1 more source
Natural history of gastro‐oesophageal reflux disease diagnosed in general practice [PDF]
Alimentary Pharmacology & Therapeutics, 2004 SummaryBackground : Cross‐sectional studies indicate that gastro‐oesophageal reflux disease symptoms have a prevalence of 10–20% in Western countries and are associated with obesity, smoking, oesophagitis, chest pain and respiratory disease.Aim : To determine the natural history of gastro‐oesophageal reflux disease presenting in primary care in the UK ...
Ruigomez, A. +5 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Natural History of Patients with X-ray-negative Dyspepsia in General Practice [PDF]
BMJ, 1972 When 102 patients with dyspepsia who had normal findings on barium-meal examination in 1964 were interviewed in 1970, 85 of them (76%) were symptomatically improved, and only three were later shown to have a peptic ulcer. This suggests that "x-ray-negative dyspepsia" has a good prognosis in a general practice setting.
D W, Gregory +3 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Learning the natural history of human disease with generative transformers
NatureAbstract Decision-making in healthcare relies on the ability to understand patients’ past and current health state to predict, and ultimately change, their future course. Artificial intelligence (AI) methods promise to aid this task by learning patterns of disease progression from large corpora of health records to predict detailed ...
Artem Shmatko +7 more
openaire +5 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
General guide to the exhibition halls of the American Museum of Natural History;
, 1911 Eleventh and 12th eds. have title: Guide to the present exhibition halls of the American Museum of Natural History (with cover title: General guide to the exhibition halls); 1939 ed.
American Museum of Natural History.
openaire +3 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source