Results 41 to 50 of about 3,617,486 (301)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Bayesian inference of natural selection from allele frequency time series
, 2016 The advent of accessible ancient DNA technology now allows the direct ascertainment of allele frequencies in ancestral populations, thereby enabling the use of allele frequency time series to detect and estimate natural selection.
Evans, Steven N. +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Interpretation of evolution as part of science popularization in natural history museums
Geo&Bio, 2021 The paper presents a brief review of the scientific and educational role of natural history museums, particularly in the field of interpretation of organic evolution.
Z. Barkaszi, O. Kovalchuk, A. Maliuk
doaj +1 more source
Data handling methods and target detection results for multibeam and sidescan data collected as part of the search for SwissAir Flight 111 [PDF]
, 1999 The crash of SwissAir Flight 111, off Nova Scotia in September 1998, triggered one of the largest seabed search surveys in Canadian history. The primary search tools used were sidescan sonars (both conventional and focussed types) and multibeam sonars ...
Bradford, Jim +5 more
core +1 more source
The use of historical collections to estimate population trends: a case study using Swedish longhorn beetles (Coleoptera: Cerambycidae) [PDF]
, 2010 Long term data to estimate population trends among species are generally lacking. However, Natural History Collections (NHCs) can provide such information, but may suffer from biases due to varying sampling effort.
Forslund, Pär +3 more
core +1 more source
Building Next-Generation Collections: Natural History Specimens, Just One Click Away! [PDF]
Biodiversity Information Science and Standards, 2018 Digitisation has made significant advances in many natural history collections since the 1980s. The Vertebrate Zoology Collections team of the Canadian Museum of Nature (CMNVZC; ca. 1,250,000 catalogued specimens) has the ambition to go fully digital with our physical objects and associated data.
Khidas,Kamal, Tessier,Stéphanie
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Designing out the urban heat island effect [PDF]
, 2012 As the global population reaches an all time high and shows no sign of slowing, and the urban population outnumbers the rural population for the first time in human history, the social, economic and environmental issues faced by those living in urban ...
Grierson, David, Munro, Karen Elizabeth
core
Rigid motion revisited: rigid quasilocal frames
, 2008 We introduce the notion of a rigid quasilocal frame (RQF) as a geometrically natural way to define a "system" in general relativity. An RQF is defined as a two-parameter family of timelike worldlines comprising the worldtube boundary of the history of a ...
Bel Ll +12 more
core +1 more source