Results 61 to 70 of about 22,064,156 (269)

Natural History of Congenital Generalized Lipodystrophy: A Nationwide Study From Turkey

The Journal of Clinical Endocrinology & Metabolism, 2016
Context: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by near-total lack of body fat. Objective: We aimed to study natural history and disease burden of various subtypes of CGL.
TUYSUZ, B, ONAY, H, MIHCI, E, DEMIR, Lütfü, OZEN, S, KAYSERILI, H, GARG, A, AKINCI, G, ATMACA, H, TOPALOGLU, H, NUR, B, ATMACA, M, ALTAY, C, SIMSEK, E, Nuri, Ozbek, GUNGOR, A, Yildirim, Simsir, ASLANGER, A, ALTUNOGLU, U, SECIL, M, SAYGILI, F, CAVDAR, U, AKINCI, B, DEMIR, T, ATIK, T, COMLEKCI, A, Bilen, Habib   +26 more
openaire   +7 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

The oldest known site of the Roman snail (Helix pomatia L.) in the Ślęża Mountain (SW Poland)

European Journal of Biological Research, 2019
Study on the distribution of the Roman snail in the Ślęża Massif was carried out in 2016. The species was recorded at the foot of the Ślęża and Radunia Mountains, on their slopes (to the 300 m a.s.l.) and at the top of the Ślęża Mountain.
Jerzy Błoszyk, Szymon Konwerski, Joanna Gogol, Agnieszka Napierała   +3 more
doaj  

Species Diversity and Spatial Distribution of Some Oribatid Mites in Bory Tucholskie National Park (N Poland)

Diversity
There are 23 national parks in Poland, and only a few of them have been studied thoroughly with regard to acarofauna so far. One of the least-examined areas in this regard is Bory Tucholskie National Park (BTNP), established in 1996.
Wojciech Niedbała, Agnieszka Napierała, Jacek Wendzonka, Karolina Lubińska, Marta Kulczak, Jerzy Błoszyk   +5 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Digging into the evolutionary history of the fungus-growing-ant symbiont, Escovopsis (Hypocreaceae)

Communications Biology
Symbiotic relationships shape the evolution of organisms. Fungi in the genus Escovopsis share an evolutionary history with the fungus-growing “attine” ant system and are only found in association with these social insects. Despite this close relationship,
Quimi Vidaurre Montoya, Nicole Marie Gerardo, Maria Jesus Sutta Martiarena, Claudia Solís-Lemus, Ricardo Kriebel, Ted R. Schultz, Jeffrey Sosa-Calvo, Andre Rodrigues   +7 more
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source