Results 51 to 60 of about 641,261 (289)

Natural History of Congenital Generalized Lipodystrophy: A Nationwide Study From Turkey

The Journal of Clinical Endocrinology & Metabolism, 2016
Context: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by near-total lack of body fat. Objective: We aimed to study natural history and disease burden of various subtypes of CGL.
TUYSUZ, B, ONAY, H, MIHCI, E, DEMIR, Lütfü, OZEN, S, KAYSERILI, H, GARG, A, AKINCI, G, ATMACA, H, TOPALOGLU, H, NUR, B, ATMACA, M, ALTAY, C, SIMSEK, E, Nuri, Ozbek, GUNGOR, A, Yildirim, Simsir, ASLANGER, A, ALTUNOGLU, U, SECIL, M, SAYGILI, F, CAVDAR, U, AKINCI, B, DEMIR, T, ATIK, T, COMLEKCI, A, Bilen, Habib   +26 more
openaire   +6 more sources

British Museum (Natural History): General and Departmental Libraries [PDF]

Nature, 1930
WITH reference to a review, appearing in the Supplement to NATURE for Oct. 4, of the list of place-numbers of societies issuing serial publications contained in the General Library of the British Museum (Natural History), I have been desired to point out that this List, being a General Library List, does not include the more special serials housed in ...
openaire   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Interpretation of evolution as part of science popularization in natural history museums

Geo&Bio, 2021
The paper presents a brief review of the scientific and educational role of natural history museums, particularly in the field of interpretation of organic evolution.
Z. Barkaszi, O. Kovalchuk, A. Maliuk
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Connotation and qualities of the Buddhist culture of Grand Canal

HTS Teologiese Studies/Theological Studies
The Buddhist culture of the Grand Canal arises from the interaction and dynamic interplay between Grand Canal culture and Buddhist culture. This cultural phenomenon is not merely a simple superimposition of two elements; rather, it represents a unique ...
Bosen Qiu, Di Lang
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

At the Edge of Resilience: Making Sense of COVID-19 from the Perspective of Environmental History

Journal for the History of Environment and Society, 2020
Natural disasters nearly always catch societies by surprise, even though in hindsight historians invariably conclude that being caught off-guard in this way was in fact unfounded as both the existence of the natural hazard which caused the disaster, and ...
Tim Soens, Raf De Bont, Maïka De Keyzer
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source