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Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function

BMC Immunology, 2019
Background Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors.
Alexandra Tremblay-McLean, Sita Coenraads, Zahra Kiani, Franck P. Dupuy, Nicole F. Bernard   +4 more
doaj   +2 more sources

Glycolysis and Oxidative Phosphorylation Play Critical Roles in Natural Killer Cell Receptor-Mediated Natural Killer Cell Functions

Frontiers in Immunology, 2020
Natural killer (NK) cells are innate lymphocytes that directly kill tumor and pathogen-infected cells upon activation by cytokines and NK cell receptors (NKRs) without previous sensitization.
Zixi Wang, Zixi Wang, Di Guan, Di Guan, Shu Wang, Louis Yi Ann Chai, Louis Yi Ann Chai, Shengli Xu, Shengli Xu, Kong-Peng Lam, Kong-Peng Lam   +10 more
doaj   +2 more sources

Nanomaterial assisted natural killer cell therapy [PDF]

Frontiers in Immunology
The rising incidence of cancer has heightened interest in immune cell therapy, particularly the role of natural killer (NK) cells, which are essential components of the immune system.
Xuan Yu, Xiaobo Chen, Yanlong Yang, Yingsong Tian, Jie Jia, Xinghe Tong   +5 more
doaj   +2 more sources

Natural killer cell biology and therapy in multiple myeloma: challenges and opportunities [PDF]

Experimental Hematology & Oncology
Despite therapeutic advancements, multiple myeloma (MM) remains incurable. NK cells have emerged as a promising option for the treatment of MM. NK cells are heterogenous and typically classified based on the relative expression of their surface markers ...
Kamlesh Bisht, Aimee Merino, Rob Igarashi, Laurent Gauthier, Marielle Chiron, Alexandre Desjonqueres, Eric Smith, Edward Briercheck, Rizwan Romee, Evren Alici, Eric Vivier, Michael O’Dwyer, Helgi van de Velde   +12 more
doaj   +2 more sources

Natural killer-cell counts are associated with molecular relapse-free survival after imatinib discontinuation in chronic myeloid leukemia: the IMMUNOSTIM study

Haematologica, 2017
Despite persistence of leukemic stem cells, patients with chronic myeloid leukemia who achieve and maintain deep molecular responses may successfully stop the tyrosine kinase inhibitor imatinib.
Delphine Rea, Guylaine Henry, Zena Khaznadar, Gabriel Etienne, François Guilhot, Franck Nicolini, Joelle Guilhot, Philippe Rousselot, Françoise Huguet, Laurence Legros, Martine Gardembas, Viviane Dubruille, Agnès Guerci-Bresler, Aude Charbonnier, Frédéric Maloisel, Jean-Christophe Ianotto, Bruno Villemagne, François-Xavier Mahon, Hélène Moins-Teisserenc, Nicolas Dulphy, Antoine Toubert   +20 more
doaj   +2 more sources

The early expansion of anergic NKG2Apos/CD56dim/CD16neg natural killer represents a therapeutic target in haploidentical hematopoietic stem cell transplantation [PDF]

Haematologica, 2018
Natural killer cells are the first lymphocyte population to reconstitute early after non-myeloablative and T cell-replete haploidentical hematopoietic stem cell transplantation with post-transplant infusion of cyclophosphamide.
Alessandra Roberto, Clara Di Vito, Elisa Zaghi, Emilia Maria Cristina Mazza, Arianna Capucetti, Michela Calvi, Paolo Tentorio, Veronica Zanon, Barbara Sarina, Jacopo Mariotti, Stefania Bramanti, Elena Tenedini, Enrico Tagliafico, Silvio Bicciato, Armando Santoro, Mario Roederer, Emanuela Marcenaro, Luca Castagna, Enrico Lugli, Domenico Mavilio   +19 more
doaj   +6 more sources

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing αβ+T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies

Haematologica, 2016
We analyzed the impact of human cytomegalovirus infection on the development of natural killer cells in 27 pediatric patients affected by hematological malignancies, who had received a HLA-haploidentical hematopoietic stem cell transplantation, depleted ...
Letizia Muccio, Alice Bertaina, Michela Falco, Daniela Pende, Raffaella Meazza, Miguel Lopez-Botet, Lorenzo Moretta, Franco Locatelli, Alessandro Moretta, Mariella Della Chiesa   +9 more
doaj   +2 more sources

Natural killer cells in antitumour adoptive cell immunotherapy

Nature Reviews. Cancer, 2022
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with intrinsic abilities to identify and eliminate virally infected cells and tumour cells.
Tamara J Laskowski, Alexander Biederstädt, K. Rezvani   +2 more
semanticscholar   +1 more source

Allogeneic natural killer cell therapy

Blood, 2022
Visual ...
M. Berrien-Elliott, Miriam T. Jacobs, T. Fehniger   +2 more
semanticscholar   +1 more source

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

Nature, 2009
Marina Cella, William Vermi, Fabio Facchetti   +2 more
exaly   +2 more sources