Results 11 to 20 of about 229,882 (218)

Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT

Nature Communications, 2022
Natural killer cells have emerged as critical immune cells in the response to fungal infection. Here the authors identify how Candida albicans evades the natural killer cell response via expression of ligands that directly modify the natural killer cell ...
Yoav Charpak-Amikam, Tom Lapidus, Batya Isaacson, Alexandra Duev-Cohen, Tal Levinson, Adi Elbaz, Francesca Levi-Schaffer, Nir Osherov, Gilad Bachrach, Lois L. Hoyer, Maya Korem, Ronen Ben-Ami, Ofer Mandelboim   +12 more
doaj   +1 more source

Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity

Haematologica, 2009
Background Bortezomib is a selective and potent inhibitor of the proteasome and has prominent effects in vitro and in vivo against tumors. Very recently, cytotoxic effects of bortezomib on immune-competent cells such as T cells and dendritic cells were ...
Xiangling Wang, Astrid Ottosson, Chunyan Ji, Xiaoli Feng, Magnus Nordenskjöld, Jan-Inge Henter, Bengt Fadeel, Chengyun Zheng   +7 more
doaj   +1 more source

Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

PLoS ONE, 2019
Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka, Tsutomu Nakazawa, Mitsutoshi Nakamura, Fumihiko Nishimura, Ryosuke Matsuda, Koji Omoto, Yoichi Shida, Toshiharu Murakami, Ichiro Nakagawa, Yasushi Motoyama, Hiromichi Morita, Takahiro Tsujimura, Hiroyuki Nakase   +12 more
doaj   +1 more source

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source

Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphoma and establishes MIR155HG as a target of PRDM1

Tumor Biology, 2017
Natural killer/T-cell lymphoma is a rare but aggressive neoplasm with poor prognosis. Despite previous reports that showed potential tumor suppressors, such as PRDM1 or oncogenes associated with the etiology of this malignancy, the role of long non ...
Esra Baytak, Qiang Gong, Burcu Akman, Hongling Yuan, Wing C Chan, Can Küçük   +5 more
doaj   +1 more source

Natural Killer Cell Transfer Assay

Bio-Protocol, 2013
Natural Killer (NK) cells are cytotoxic lymphocytes that constitute a major component of the innate immune system. Immunosurveillance of the host by NK cells for malignant and virally-infected cells results in direct cytotoxicity and the production of ...
Lee-Hwa Tai, Christiano Souza, Andrew Makrigiannis, Rebecca Auer   +3 more
doaj   +1 more source

CAR natural killer cell therapy: Natural killer cell activation and expansion

Acta Biomedica Scientifica
Currently, chimeric antigen receptor (CAR) T-cell therapy is an effective treatment method of hematological malignancies. However, T-lymphocyte-based immunotherapy has certain limitations for the scope of application of this approach.
P. O. Fedorova
doaj   +1 more source

Pralatrexate as a bridge to allogeneic hematopoietic stem cell transplantation in a patient with advanced-stage extranodal nasal-type natural killer/T cell lymphoma refractory to first-line chemotherapy: a case report

Journal of Medical Case Reports, 2020
Background Extranodal natural killer/T cell lymphoma, nasal type, is one of the more common subtypes of mature T cell lymphoma, especially in the Far East Asian population.
Yao-Chung Liu, Ting-An Lin, Hao-Yuan Wang, Po-Shen Ko, Chia-Jen Liu, Liang-Tsai Hsiao, Sheng-Hsuan Chien, Jyh-Pyng Gau   +7 more
doaj   +1 more source

Advances in augmenting infiltration of active natural killer cells into pediatric and adult solid tumors

Molecular Therapy: Oncology
Although adoptive natural killer cell therapies have been safe and somewhat effective in hematological malignancies, their performance in solid tumors is hindered by the solid tumor microenvironment, which impairs natural killer cell trafficking and ...
Shiori Eguchi, Wen Luo, Hongwen Zhu, Jeremy M. Rosenblum, Anna R. Cooper, Mitchell S. Cairo   +5 more
doaj   +1 more source

Detection of monoclonal T populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells

Haematologica, 2014
The etiology of chronic large granular lymphocyte proliferations is largely unknown. Although these disorders are characterized by the expansion of different cell types (T and natural killer) with specific genetic features and abnormalities, several ...
Cristina Gattazzo, Antonella Teramo, Francesca Passeri, Elena De March, Samuela Carraro, Valentina Trimarco, Federica Frezzato, Tamara Berno, Gregorio Barilà, Veronica Martini, Francesco Piazza, Livio Trentin, Monica Facco, Gianpietro Semenzato, Renato Zambello   +14 more
doaj   +1 more source