Results 11 to 20 of about 414,040 (306)
Natural Killer Cell Memory [PDF]
Immunity, 2015 Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of
O’Sullivan, Timothy E +2 more
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Targeting natural killer cells and natural killer T cells in cancer [PDF]
Nature Reviews Immunology, 2012 Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share some phenotypical and functional similarities. Both cell types can rapidly respond to the presence of tumour cells and participate in antitumour immune responses. This has prompted interest in the development of innovative cancer therapies that are based on
Vivier, Eric +4 more
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The activating receptors 2B4 and NTB-A, but not CRACC are subject to ligand-induced down-regulation on human natural killer cells [PDF]
, 2010 Activation of natural killer cells can be mediated by different receptors. Stimulation of the receptors 2B4, NTB-A and CRACC, members of the SLAM-related receptor family, induces cytotoxicity and cytokine production.
Carolin Böhm +4 more
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SnapShot: Natural Killer Cells
Cell, 2020 NK cells are broadly distributed innate lymphoid cells (ILCs) encompassing distinct populations based on CD11b and CD27 expression in mice or CD56 intensity in humans. Involved in anti-viral and anti-tumor immunity thanks to their cytokines and chemokines secretion as well as their cytotoxic capabilities, NK cells have emerged as a promising ...
Crinier, Adeline +3 more
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Natural Killer T and Natural Killer Cell-Based Immunotherapy Strategies Targeting Cancer
Biomolecules, 2023 Both natural killer T (NKT) and natural killer (NK) cells are innate cytotoxic lymphoid cells that produce inflammatory cytokines and chemokines, and their role in the innate immune response to tumors and microorganisms has been investigated. Especially,
Tomonori Iyoda +4 more
doaj +1 more source
Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis. [PDF]
, 2017 Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or ...
Molfetta, R +3 more
core +2 more sources
Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster. [PDF]
PLoS ONE, 2018 The pathogenesis of herpes zoster is closely linked to reduced varicella-zoster virus-specific cell-mediated immunity. However, little is known about the interplay between natural killer cells and psychological stress in the pathogenesis of herpes zoster.
Choon Kwan Kim +5 more
doaj +1 more source
Evasion of NK cell immune surveillance via the vimentin-mediated cytoskeleton remodeling
Frontiers in Immunology, 2022 Cancer immunotherapy uses the immune system to achieve therapeutic effects; however, its effect is still limited. Therefore, in addition to immune checkpoint-based treatment, the development of other strategies that can inhibit cancer cells from ...
Jei-Ming Peng +8 more
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Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation
Frontiers in Immunology, 2017 Natural killer (NK) cells are a promising tool for the use in adoptive immunotherapy, since they efficiently recognize and kill tumor cells. In this context, ex vivo cultivation is an attractive option to increase NK cells in numbers and to improve their
Markus Granzin +8 more
doaj +1 more source
Current landscape of clinical use of ex vivo expanded natural killer cells for cancer therapy [PDF]
Einstein (São Paulo)Natural Killer cells are immune leukocytes required for responses against tumor cells and virus-infected cells. In the last decade, natural killer cells have emerged as promising tools in cancer therapy, and clinical studies on patients treated with ...
Júlia Teixeira Cottas de Azevedo +11 more
doaj +1 more source