Results 31 to 40 of about 749,043 (396)

Natural killer cells [PDF]

Current Biology, 1999
Perhaps, but probably not a long or healthy life. There is only one documented human case of an absolute NK cell deficiency, which was associated with recurrent life-threatening bacterial and viral infections.
openaire   +3 more sources

Current landscape of clinical use of ex vivo expanded natural killer cells for cancer therapy [PDF]

Einstein (São Paulo)
Natural Killer cells are immune leukocytes required for responses against tumor cells and virus-infected cells. In the last decade, natural killer cells have emerged as promising tools in cancer therapy, and clinical studies on patients treated with ...
Júlia Teixeira Cottas de Azevedo, Juliana Aparecida Preto de Godoy, Cláudia de Souza, Micheli Severo Sielski, Larissa Leggieri Coa, Augusto Barbosa Júnior, Lucila Nassif Kerbauy, Andrea Tiemi Kondo, Oswaldo Keith Okamoto, Nelson Hamerschlak, José Mauro Kutner, Raquel de Melo Alves Paiva   +11 more
doaj   +1 more source

Trispecific natural killer cell nanoengagers for targeted chemoimmunotherapy

Science Advances, 2020
A trispecific natural killer cell engager platform has been successfully engineered for EGFR-targeted chemoimmunotherapy. Activation of the innate immune system and natural killer (NK) cells has been a key effort in cancer immunotherapy research.
K. M. Au, Steven I. Park, Andrew Z. Wang
semanticscholar   +1 more source

The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I [PDF]

, 2006
The major histocompatibility complex (MHC) class I region in mammals contains both classical and non-classical MHC class I genes. Classical MHC class I molecules present antigenic peptides to cytotoxic T lymphocytes, whereas non-classical MHC class I ...
Anderson, Araibi, Ashrafi, Ashrafi, Ashrafi, B. Marchetti, Borrego, Cohen, Davies, Di Palma, E.H. Araibi, E.S. Dornan, Ellis, Ellis, Ellis, Frazer, G.H. Ashrafi, Geraghty, Hofmeister, M. Dobromylskyj, M.S. Campo, Marchetti, Marchetti, McQueen, O'Brien, Pennie, Piguet, Pizzato, Riteau, Roeth, S.A. Ellis, Storset, Storset, Tindle, Tomasec, Toye, Wang, Williams   +37 more
core   +1 more source

Lymphokine-activated killer cell phenomenon. Lysis of natural killer- resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes

Journal of Experimental Medicine, 1982
Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from cancer patients or normal individuals resulted in expression of cytotoxicity toward 20 of 21 natural killer (NK)-resistant fresh ...
E. Grimm, A. Mazumder, Hua Zhang, S. Rosenberg   +3 more
semanticscholar   +1 more source

Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis. [PDF]

, 2017
Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or ...
Molfetta, R, Paolini, R., Quatrini, L, Santoni, A   +3 more
core   +2 more sources

SnapShot: Natural Killer Cells

Cell, 2020
NK cells are broadly distributed innate lymphoid cells (ILCs) encompassing distinct populations based on CD11b and CD27 expression in mice or CD56 intensity in humans. Involved in anti-viral and anti-tumor immunity thanks to their cytokines and chemokines secretion as well as their cytotoxic capabilities, NK cells have emerged as a promising ...
Crinier, Adeline, Narni-Mancinelli, Emilie, Ugolini, Sophie, Vivier, Eric   +3 more
openaire   +3 more sources

The trafficking of natural killer cells [PDF]

Immunological Reviews, 2007
Summary: Natural killer (NK) cells are large granular lymphocytes of the innate immune system that participate in the early control of microbial infections and cancer. NK cells can induce the death of autologous cells undergoing various forms of stress, recognizing and providing non‐microbial ‘danger’ signals to the immune system.
Frederic Geissmann, Thierry Walzer, Thierry Walzer, Claude Grégoire, Eric Vivier, Lionel Chasson, Lionel Chasson, Elena Tomasello, Elena Tomasello, Carmelo Luci, Carmelo Luci   +10 more
openaire   +3 more sources

Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity

Haematologica, 2009
Background Bortezomib is a selective and potent inhibitor of the proteasome and has prominent effects in vitro and in vivo against tumors. Very recently, cytotoxic effects of bortezomib on immune-competent cells such as T cells and dendritic cells were ...
Xiangling Wang, Astrid Ottosson, Chunyan Ji, Xiaoli Feng, Magnus Nordenskjöld, Jan-Inge Henter, Bengt Fadeel, Chengyun Zheng   +7 more
doaj   +1 more source

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source