Results 251 to 260 of about 259,208 (317)

Mannose-binding lectin 2 secreted by hepatocellular carcinoma cells recruits and activates natural killer cells to reshape an immune-activated microenvironment. [PDF]

PLoS Biol
Liao H, Yang J, Cai L, Chi L, Wang C, Xu Y, Xie J, Chen K, Pei J, Jiang Z, Pan M, Zhao L.   +11 more
europepmc   +1 more source

Water‐Enabled Ultralong Full‐Color Organic Phosphorescence in Hydrogen‐Bonded Frameworks for 4D Encryption and Bio‐Imaging

Advanced Science, EarlyView.
Water‐induced quenching challenges organic RTP materials, but a counter‐intuitive strategy employs HOF to encapsulate carbonyl guests, where water functions as a structural reinforcer. This achieves water‐enhanced ultralong RTP with full‐color emission (blue to deep red), overcoming intracellular quenching for high‐signal cellular imaging, alongside 4D
Pengcheng Wu, Zenggang Lin, Lu Yang, Weisheng Liu   +3 more
wiley   +1 more source

Tissue localization of natural killer cells dictates surveillance of lung metastasis. [PDF]

Nat Commun
Vermeer M, Sparano C, Coianiz N, Mayoux M, Litscher G, Fonseca A, Dergun S, Mussak C, Rindlisbacher L, Häne P, Ducimetière L, Wertheimer T, Becher B, Dieterich LC, Tugues S.   +14 more
europepmc   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Alpha-Fetoprotein Stimulates Cleavage of Membranal MICA/B on Liver Cancer Cell Lead to Escape Immune Surveillance of Natural Killer Cells. [PDF]

J Cell Mol Med
Li X, Feng S, Wu X, Pan Y, Zhou Y, Liu K, Lin B, Li W, Li M, Zhu M.   +9 more
europepmc   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

An innovative treatment for lung cancer using gene-engineered human-induced pluripotent stem cell-derived natural killer cells. [PDF]

Cancer Immunol Immunother
Sato Y, Goto K, Yagishita S, Miyata K, Uesugi N, Torisawa YS, Naritomi Y, Takahashi R, Sho R, Takeno Y, Kurachi K, Yamada M, Higashi Y, Kimura H, Hamada A, Nishigaki F, Tamura K.   +16 more
europepmc   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Decoding the multifaceted cellular and transcriptomic variations of natural killer cells generated from patients with Parkinson's disease. [PDF]

Sci Rep
Yue X, Hu Q, Cheng H, Su G, Diao J, Du Y, Fu P, Wang P, Zhang L, Zhou Q.   +9 more
europepmc   +1 more source

Insomnia and anxiety: exploring their hidden effect on natural killer cells among young female adults. [PDF]

Front Immunol
Alhamawi RM, Halawani FA, Hakeem SF, Alslimi HA, Alhamawi EM, Aljohani AM, Mohammed IN, Zahid HM, Almutawif YA.   +8 more
europepmc   +1 more source