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Natural killer cell metabolism
Molecular Immunology, 2019Natural killer (NK) cells are a critical component in the innate immune response against disease. NK cell function is tightly regulated by specific cytokine and activation/inhibitory receptor signalling, leading to diverse effector responses. Like all living cells, energy metabolism is a fundamental requirement for NK cell activation and survival ...
Kobayashi, Takumi +1 more
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Natural killer cells and reproduction
Trends in Immunology, 2002Abstract The Cambridge Immunology and Reproductive Immunology Groups of the British Society for Immunology held a meeting on NK Cells and Reproduction at King's College, Cambridge, UK, on 2–4 April, 2002.
Ashley, Moffett-King +4 more
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Natural Killer Cells and Cancer
2003Natural killer (NK) cells are lymphocytes that were first identified for their ability to kill tumor cells without deliberate immunization or activation. Subsequently, they were also found to be able to kill cells that are infected with certain viruses and to attack preferentially cells that lack expression of major histocompatibility complex (MHC ...
Jun, Wu, Lewis L, Lanier
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Natural killer cells in cancer
Seminars in Cancer Biology, 2006Publisher Summary Integrated with other immune cells, natural killer (NK) cells contribute to host anti-microbial and anti- tumor immunity. The provision of early defence mechanisms against viral infections, particularly herpes viruses, is perhaps the most important clinical effect by NK cells, but it was their cytotoxic potency against tumor cells ...
Petter, Höglund, Eva, Klein
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Current Opinion in Immunology, 1995
In killing of cellular targets, natural killer cells employ receptors that activate them and receptors specific for MHC class I that inhibit their activation. Progress in understanding the inhibitory receptors has been rapid, and indications are that they fall into two distinct structural types that appear to utilize the same inhibitory signaling ...
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In killing of cellular targets, natural killer cells employ receptors that activate them and receptors specific for MHC class I that inhibit their activation. Progress in understanding the inhibitory receptors has been rapid, and indications are that they fall into two distinct structural types that appear to utilize the same inhibitory signaling ...
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Natural Killer Cells for Osteosarcoma
2014Natural killer (NK) cells are lymphocytes of the innate immune system that have the ability to recognize malignant cells through detection of a variety of cell-surface indicators of stress and danger. Once activated through such recognition, NK cells release cytokines and induce target cell lysis through a variety of mechanisms.
Nidale, Tarek, Dean A, Lee
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Natural killer cells and autoimmunity
Immunologic Research, 1989In various autoimmune diseases it appears that NK activity is impaired, and that this phenomenon is significant in disease development. Impairment of NK activity may be the result of two different mechanisms. In systemic autoimmune diseases, in which various target organs are involved (nonorgan-specific), the peripheral blood NK level is generally ...
E, Grunebaum +2 more
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Natural killer cells and their receptors
Transplant Immunology, 2002Natural killer (NK) cells have been known for a long time to be a very important component of the innate immune system. However, it is only during the last 10 years that knowledge of their receptors has emerged. Described in the present review are those receptor families killer inhibitory receptor (KIR) (belonging to the immunoglobulin superfamily ...
Derek, Middleton +2 more
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Improving natural killer cells
Cytotherapy, 2008Donor lymphocyte infusions after stem cell transplantation have taught the cancer community that human immune cells have the potential power to control growth of and even eliminate a malignant clone. Although infusion of allogeneic T lymphocytes after stem cell transplantation has become part of the treatment algorithm, either to prevent or treat ...
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The enigma of the natural killer cell
Nature, 1995Natural killer (NK) cells are controlled by receptors specific for polymorphic determinants of class I molecules of the major histocompatibility complex (MHC). The contrasting properties of NK and cytotoxic T cell (CTL) class I receptors provide complementarity in the cytolytic lymphocyte response to viruses, tumours and transplants.
J E, Gumperz, P, Parham
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