Results 211 to 220 of about 213,838 (267)

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Primary Extranodal Natural Killer/T-Cell Lymphoma of the Central Nervous System: A Rare Case Report with Diagnostic and Management Challenges [PDF]

Turk J Haematol
Dahiya S, Langer S, Saraf A, Arya V, Ranjan R, Kotwal J.   +5 more
europepmc   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Development of a Radiomic-clinical Nomogram for Prediction of Survival in Patients with Nasal Extranodal Natural Killer/T-cell Lymphoma [PDF]

Curr Med Imaging
Chen L, Wang Z, Fang X, Yu M, Ye H, Han L, Tian Y, Guo C, He H.   +8 more
europepmc   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Baseline total lesion glycolysis identifies high-risk patients with immunosuppressive signatures in early-stage natural killer/T-cell lymphoma. [PDF]

Oncologist
Gao X, Xiong J, Huang XY, Yang HX, Zhong HJ, Cheng S, Jiang XF, Zhao WL.   +7 more
europepmc   +1 more source

The Usefulness of 2-[18F]FDG PET or PET/CT in Extranodal Natural Killer/T-Cell Lymphoma: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Albano D, Rodella C, Tucci A, Treglia G, Bertagna F, Chiti A, Fallanca F.   +6 more
europepmc   +1 more source

Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases. [PDF]

Oncol Lett
Wen Q, Li Q, Yang W, Chang X, Zhu F, Pan H, Zhang L.   +6 more
europepmc   +1 more source

Inhibiting Invariant Natural Killer T-Cell Activation: A Promising Strategy against Pulmonary Fibrosis. [PDF]

Am J Respir Crit Care Med
Yasuma T, Fujimoto H, D'Alessandro-Gabazza CN, Gabazza EC, Hataji O, Kobayashi T.   +5 more
europepmc   +1 more source

Extranodal natural killer/T-cell lymphoma with tonsil involvement: a case report. [PDF]

BMC Oral Health
Xiao Y, Zhang X, Gao Y, Lin K, Chi W, Zhou K, Ma J, Zhang T.   +7 more
europepmc   +1 more source