Results 261 to 270 of about 230,055 (317)

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

LMP1 enhances aerobic glycolysis in natural killer/T cell lymphoma. [PDF]

Cell Death Dis
Song W, Gao Y, Wu J, Li H, Shi Z, Gong C, Zhang Z, Li Z, Zhang M.   +8 more
europepmc   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Development of a Radiomic-clinical Nomogram for Prediction of Survival in Patients with Nasal Extranodal Natural Killer/T-cell Lymphoma [PDF]

Curr Med Imaging
Chen L, Wang Z, Fang X, Yu M, Ye H, Han L, Tian Y, Guo C, He H.   +8 more
europepmc   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Baseline total lesion glycolysis identifies high-risk patients with immunosuppressive signatures in early-stage natural killer/T-cell lymphoma. [PDF]

Oncologist
Gao X, Xiong J, Huang XY, Yang HX, Zhong HJ, Cheng S, Jiang XF, Zhao WL.   +7 more
europepmc   +1 more source

The Usefulness of 2-[18F]FDG PET or PET/CT in Extranodal Natural Killer/T-Cell Lymphoma: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Albano D, Rodella C, Tucci A, Treglia G, Bertagna F, Chiti A, Fallanca F.   +6 more
europepmc   +1 more source

Composite B‑cell lymphoma and extranodal natural killer/T‑cell lymphoma presenting with distinct clone evolution and tumor microenvironment: A report of two cases. [PDF]

Oncol Lett
Wen Q, Li Q, Yang W, Chang X, Zhu F, Pan H, Zhang L.   +6 more
europepmc   +1 more source

Inhibiting Invariant Natural Killer T-Cell Activation: A Promising Strategy against Pulmonary Fibrosis. [PDF]

Am J Respir Crit Care Med
Yasuma T, Fujimoto H, D'Alessandro-Gabazza CN, Gabazza EC, Hataji O, Kobayashi T.   +5 more
europepmc   +1 more source

High-risk extranodal natural killer/T-cell lymphoma patients could benefit more from allogeneic hematopoietic stem cell transplantation as consolidation: A real-world multicenter analysis in China. [PDF]

Chin J Cancer Res
Wang Y, Xia Y, Gu Z, Chang Y, Yang L, Yang P, Zhao Y, Zhang C, Wang N, Yang S, Yang Y, Jiang C, Cao L, Deng D, Lu H, Wang F, Zhang M, Cao Y, Hu X, Niu T, Mo X.   +20 more
europepmc   +1 more source