Results 31 to 40 of about 600,571 (264)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

TEAM: A Transportable Natural Language Interface System [PDF]

open access: yes, 1983
A major benefit of using natural language to access the information in a database is that it shifts onto the system the burden of mediating between two views of the data: the way in which the data is stored (the "database view"), and the way in which an ...
Barbara J. Grosz, Grosz, Barbara
core   +1 more source

Improving negative rejection ability in language models: A review of fine-tuned LLMs, RAG, and RAFT

open access: yesJournal of King Saud University: Computer and Information Sciences
Large Language Models (LLMs) excel in text understanding and generation but struggle to reject irrelevant, ambiguous, or misleading queries, termed negative rejection, impacting reliability in high-stakes contexts.
Li Bowen   +4 more
doaj   +1 more source

Validity of the laws of Non-contradiction and Excluded middle; Logical or Psychological (Review of misunderstandings and misinterpretations, self-made accusations and types of fallacies in a criticism) [PDF]

open access: yesحکمت معاصر
In Classical Logic, the law of non-contradiction and the law of excluded middle are considered theorems and have proof. Recently, Morteza Hajihosseini has written a book titled Two Non-Classical Logic Systems, A New Outlook on Elements of Logic (2017 ...
Morteza Hajihosseini   +1 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Natural causes of language: Frames, biases, and cultural transmission

open access: yes, 2014
What causes a language to be the way it is? Some features are universal, some are inherited, others are borrowed, and yet others are internally innovated.
Enfield, N.J.; University of Sydney
core   +1 more source

Information Retrieval Based on Brazilian Portuguese Texts [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2022
Knowledge-based intelligent systems might be used in the banking sector to automate customer service. One of the ways to represent knowledge that is both understandable by humans and readable by machines is by using ontologies.
Victor Hayashi   +6 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Teaching and Learning of Geometry as a process of Objectification: conditions and obstacles to argumentation and proof. The role of natural language, specific language, and figures

open access: yesREMATEC. Revista de Matemática, Ensino e Cultura, 2021
This paper examines some examples (taken from research conducted over the years) that show students’ linguistic attitudes in geometry tasks. The examples are framed within the Theory of Objectification with reference to the notion of sensuous cognition,
Bruno D’Amore, George Santi
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

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