Results 51 to 60 of about 600,571 (264)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Proceedings of the 4th Clinical Natural Language Processing Workshop [PDF]

open access: yes, 2022
Acronym disambiguation (AD) is the process of identifying the correct expansion of the acronyms in text. AD is crucial in natural language understanding of scientific and medical documents due to the high prevalence of technical acronyms and the possible
Lenskiy Artem   +3 more
core  

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Towards Portable Natural Language Interfaces to Knowledge Bases - The Case of the ORAKEL System -

open access: yes, 2008
Cimiano P, Haase P, Heizmann J, Mantel M, Studer R. Towards Portable Natural Language Interfaces to Knowledge Bases - The Case of the ORAKEL System -. Data & Knowledge Engineering (DKE).
Haase, Peter   +4 more
core   +1 more source

A Systematic Comparison of Data Selection Criteria for SMT Domain Adaptation

open access: yesThe Scientific World Journal, 2014
Data selection has shown significant improvements in effective use of training data by extracting sentences from large general-domain corpora to adapt statistical machine translation (SMT) systems to in-domain data.
Longyue Wang   +4 more
doaj   +1 more source

Networked Language Communities: From Constructed Languages to Natural Languages

open access: yesГуманитарный вектор, 2022
Activities for the preservation and development of ethnic minority languages are considered as the most important part of the actions to preserve the cultural heritage of the peoples inhabiting the Russian Federation.
Marat N. Chistanov
doaj   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler   +20 more
wiley   +1 more source

Natural language processing for global and local business

open access: yes, 2020
The concept of natural language processing has become one of the preferred methods to better understand consumers, especially in recent years when digital technologies and research methods have developed exponentially.
Taşkıran, Meliha Nurdan   +1 more
core   +1 more source

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