Results 111 to 120 of about 1,083,042 (374)

Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks

Chemistry, 2017
The productive exploration of chemical space is an enduring challenge in chemical biology and medicinal chemistry. Natural products are biologically relevant, and their frameworks have facilitated chemical tool and drug discovery.
Daniel J. Foley, Philip G. E. Craven, P. Collins, R. Doveston, A. Aimon, R. Talon, I. Churcher, F. von Delft, S. Marsden, A. Nelson   +9 more
semanticscholar   +1 more source

SYNTHETIC APPROACHES TO POLIFUNCTIONALIZED PERHYDRINDANES [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2011
The current communication represents an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 31 September ...
Veaceslav Kulciţki
doaj  

The impact of natural product chemistry on medicine [PDF]

Pure and Applied Chemistry, 1967
Abstract
openaire   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Stereoselective Halogenation in Natural Product Synthesis.

Angewandte Chemie, 2016
At last count, nearly 5000 halogenated natural products have been discovered. In approximately half of these compounds, the carbon atom to which the halogen is bound is sp(3) -hybridized; therefore, there are an enormous number of natural products for ...
Won‐jin Chung, C. Vanderwal
semanticscholar   +1 more source

The crystal structure of a matrine derivative, 13-(4-Cl-pyrrole)-matrine, C18H26ClN4O

Zeitschrift für Kristallographie - New Crystal Structures, 2019
C18H26ClN4O, orthorhombic, P212121 (no. 19), a = 5.3476(1) Å, b = 14.4068(2) Å, c = 22.3285(4) Å, V = 1720.23(5) Å3, Z = 4, Rgt(F) = 0.0328, wRref(F2) = 0.0774, T = 100 K.
Jing-Min Ye, Hui-Qing He, Xu-Hong Jiang, Zhan-Mei Liu, Xing-An Cheng, Zhao-Chang He   +5 more
doaj   +1 more source

From 2015 to 2023: How Machine Learning Aids Natural Product Analysis [PDF]

arXiv
In recent years, conventional chemistry techniques have faced significant challenges due to their inherent limitations, struggling to cope with the increasing complexity and volume of data generated in contemporary research endeavors. Computational methodologies represent robust tools in the field of chemistry, offering the capacity to harness potent ...
arxiv  

The Chemistry of Natural Products related to Phenanthrene [PDF]

, 1937
Louis Fieser
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis

Angewandte Chemie, 2016
Natural products have had an immense influence on science and have directly led to the introduction of many drugs. Organic chemistry, and its unique ability to tailor natural products through synthesis, provides an extraordinary approach to unlock the ...
E. A. Crane, K. Gademann
semanticscholar   +1 more source