Results 91 to 100 of about 833,393 (296)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Computational structure-based identification of silymarin as a promising flavonoid inhibitor of the diphtheria toxin catalytic domain

Discover Chemistry
Diphtheria toxin, a major virulence factor of Corynebacterium diphtheriae, continues to pose significant therapeutic challenges in the face of antimicrobial resistance. Flavonoids, owing to their structural diversity and bioactivity, represent attractive
Chidi Edbert Duru, Favour Ogadinma Izuagba, Ijeoma Akunna Duru, Tochukwu Ifeanyi Nwakile, Chukwuebuka Daniel Nwadike   +4 more
doaj   +1 more source

Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks

Chemistry, 2017
The productive exploration of chemical space is an enduring challenge in chemical biology and medicinal chemistry. Natural products are biologically relevant, and their frameworks have facilitated chemical tool and drug discovery.
Daniel J. Foley, Philip G. E. Craven, P. Collins, R. Doveston, A. Aimon, R. Talon, I. Churcher, F. von Delft, S. Marsden, A. Nelson   +9 more
semanticscholar   +1 more source

Natural Products in Medicinal Chemistry [PDF]

Bioorganic & Medicinal Chemistry, 2009
David, Newman, Gordon, Cragg
openaire   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

The potential chemo preventive effect of ursolic acid isolated from Paulownia tomentosa, against N-diethylnitrosamine: initiated and promoted hepatocarcinogenesis

Heliyon, 2019
The present study discusses the isolation of ursolic acid from the chloroform extract of Paulownia tomentosa (Thunb) Steud fruits and its cytotoxic effect has been assessed in-vitro was performed in different cells lines (A-549, MCF-7, HepG2) and in-vivo
Sanaa A. Ali, Nabaweya A. Ibrahim, Magdy M.D. Mohammed, Seham El-Hawary, Esraa A. Refaat   +4 more
doaj   +1 more source

The flow synthesis of heterocycles for natural product and medicinal chemistry applications

Molecular diversity, 2011
This article represents an overview of recent research from the Innovative Technology Centre in the field of flow chemistry which was presented at the FROST2 meeting in Budapest in October 2009. After a short introduction of this rapidly expanding field,
M. Baumann, I. Baxendale, S. Ley
semanticscholar   +1 more source

Editorial: Advances in natural product chemistry: Yunnan University 100th anniversary. [PDF]

Front Chem, 2023
Chen W, Dong J, Panda SS.
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

New anthrarobin acyl derivatives as butyrylcholinesterase inhibitors: synthesis, in vitro and in silico studies

Heliyon, 2017
To treat Alzheimer's disease (AD), the available candidates are effective only against mild AD or have side effects. So, a study was planned to synthesis new candidates that may have good potential to treat AD.
Mehreen Lateef, Abid Azhar, Bina S. Siddiqui, Shamshad Zarina, Nizam uddin, Muhammad F. Anwar, Kauser Siddiqui, Kaniz F. Azhar, Lubna Iqbal, Rashad Mehmood, Shagufta Perveen   +10 more
doaj   +1 more source