Results 71 to 80 of about 1,054,829 (302)

Current trends in natural products research from the CBNP10 Symposium at Warwick [PDF]

, 2016
Natural products are compounds that are produced by living organisms. They have numerous applications in our everyday life, from antibiotics to herbicides.
Alberti, Fabrizio
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Aegle marmelos phytochemical stabilized synthesis and characterization of ZnO nanoparticles and their role against agriculture and food pathogen

Green Processing and Synthesis, 2019
Nature and nanotechnology have not yet achieved a lucid correlation in the field of science but together they have exhibited immense potential towards the advancement and modification in future science and technology.
Fowsiya J., Asharani I.V., Mohapatra Simron, Eshapula Akhila, Mohi Pragya, Thakar Nishant, Monad Supriyo, Madhumitha G.   +7 more
doaj   +1 more source

Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression

Heliyon, 2019
Plants of the Asteraceae family have been used in traditional medicine for centuries due to their main antimicrobial and analgesic activities. A liniment from Artemisia californica has recently been tested on patients affected by either acute pain or ...
Filomena Perri, Luca Frattaruolo, Ian Haworth, Matteo Brindisi, Asma El-magboub, Angela Ferrario, Charles Gomer, Francesca Aiello, James David Adams   +8 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Component identification and ameliorative effect of amyloid-β-induced toxicity in transgenic Caenorhabditis elegans of Ershiwuwei Zhenzhu pills

Pharmacological Research - Modern Chinese Medicine
Introduction: Alzheimer’s disease (AD) is the most common form of dementia which burdens patients’ family and society heavily. However, no effective cure for AD was proposed.
Xin Wang, Jie Yang, Hong-Fen Jiang, Yi-Nan Yang, Mi-Na Yang, Li-Jia Ye, Miao Zhang, Zhan-Xin Zhang, Jian-Ye Dai, Dong-Qing Fei   +9 more
doaj   +1 more source

Specioside (SS) & verminoside (VS) (Iridoid glycosides): isolation, characterization and comparable quantum chemical studies using density functional theory (DFT)

Heliyon, 2019
Two biologically important molecules specioside (SS) and verminoside (VS) have been isolated from the ethanolic extract of stem bark of Kigelia pinnata.
Monika Saini, Reetu Sangwan, Mohammad Faheem Khan, Ashok Kumar, Ruchi Verma, Sudha Jain   +5 more
doaj   +1 more source

A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues [PDF]

, 2017
Published in final edited form as: Bioorg Med Chem. 2017 Dec 1; 25(23): 6197–6202. Published online 2017 Jun 11. doi: [10.1016/j.bmc.2017.06.010]Herein, we report the development of continuous flow photoreactors for large scale ESIPT-mediated [3+2 ...
Beeler, Aaron B., Gao, Qiwen, Porco, John A., Yueh, Han   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification

Nature Communications, 2017
The biosynthesis of xiamycin, an antimicrobial bacterial indolosesquiterpenoid, involves an unusual cyclization cascade. Here, the authors characterise the XiaF enzyme, which resembles xenobiont-degrading enzymes and is responsible for a hidden indole ...
Susann Kugel, Martin Baunach, Philipp Baer, Mie Ishida-Ito, Srividhya Sundaram, Zhongli Xu, Michael Groll, Christian Hertweck   +7 more
doaj   +1 more source