Results 71 to 80 of about 833,393 (296)

Component identification and ameliorative effect of amyloid-β-induced toxicity in transgenic Caenorhabditis elegans of Ershiwuwei Zhenzhu pills

Pharmacological Research - Modern Chinese Medicine
Introduction: Alzheimer’s disease (AD) is the most common form of dementia which burdens patients’ family and society heavily. However, no effective cure for AD was proposed.
Xin Wang, Jie Yang, Hong-Fen Jiang, Yi-Nan Yang, Mi-Na Yang, Li-Jia Ye, Miao Zhang, Zhan-Xin Zhang, Jian-Ye Dai, Dong-Qing Fei   +9 more
doaj   +1 more source

Target Identification and Validation of (+)-2-(1-Hydroxyl-4-Oxocyclohexyl) Ethyl Caffeate, an Anti-Inflammatory Natural Product

European Journal of Inflammation, 2012
(+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate (HOEC) was isolated from Incarvillea mairei var. granditlora (Wehrhahn) Grierson. The plants of the Incarvillea genus have long been used as folk medicines for the treatment of inflammation-related ...
L. Li, H-W. Zeng, F. Liu, J-G. Zhang, R-C. Yue, W-Q. Lu, X. Yuan, W-X. Dai, H. Yuan, Q-Y. Sun, J. Huang, H-L. Li, Y-S. Li, L. Shan, W-D. Zhang   +14 more
doaj   +1 more source

Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression

Heliyon, 2019
Plants of the Asteraceae family have been used in traditional medicine for centuries due to their main antimicrobial and analgesic activities. A liniment from Artemisia californica has recently been tested on patients affected by either acute pain or ...
Filomena Perri, Luca Frattaruolo, Ian Haworth, Matteo Brindisi, Asma El-magboub, Angela Ferrario, Charles Gomer, Francesca Aiello, James David Adams   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Catalytic Markovnikov hydrophosphorylation of unactivated olefins via a radical-polar crossover rearrangement

Nature Communications
The phosphorylation of alkenes offers a diverse handle for obtaining organophosphoryls, but its regioselectivity still faces challenges, especially the radical Markovnikov hydrophosphorylation of alkenes.
Yi-Fan Li, Hong-Chen Wang, Bing Han
doaj   +1 more source

Specioside (SS) & verminoside (VS) (Iridoid glycosides): isolation, characterization and comparable quantum chemical studies using density functional theory (DFT)

Heliyon, 2019
Two biologically important molecules specioside (SS) and verminoside (VS) have been isolated from the ethanolic extract of stem bark of Kigelia pinnata.
Monika Saini, Reetu Sangwan, Mohammad Faheem Khan, Ashok Kumar, Ruchi Verma, Sudha Jain   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification

Nature Communications, 2017
The biosynthesis of xiamycin, an antimicrobial bacterial indolosesquiterpenoid, involves an unusual cyclization cascade. Here, the authors characterise the XiaF enzyme, which resembles xenobiont-degrading enzymes and is responsible for a hidden indole ...
Susann Kugel, Martin Baunach, Philipp Baer, Mie Ishida-Ito, Srividhya Sundaram, Zhongli Xu, Michael Groll, Christian Hertweck   +7 more
doaj   +1 more source

Chemical synthesis and cytotoxicity of neo-glycolipids; rare sugar-glycerol-lipid compounds

Heliyon, 2018
Rare sugars are defined as monosaccharides and their derivatives, which rarely exist in nature and have various beneficial effects on organisms, biomaterials and foods.
Keisuke Hirata, Takashi Uchida, Yoshikata Nakajima, Toru Maekawa, Toru Mizuki   +4 more
doaj   +1 more source

Tuning artificial intelligence on the de novo design of natural-product-inspired retinoid X receptor modulators

Communications Chemistry, 2018
Instances of artificial intelligence equip medicinal chemistry with innovative tools for molecular design and lead discovery. Here we describe a deep recurrent neural network for de novo design of new chemical entities that are inspired by ...
D. Merk, F. Grisoni, Lukas Friedrich, G. Schneider   +3 more
semanticscholar   +1 more source