Results 81 to 90 of about 9,230,804 (307)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Component identification and ameliorative effect of amyloid-β-induced toxicity in transgenic Caenorhabditis elegans of Ershiwuwei Zhenzhu pills

Pharmacological Research - Modern Chinese Medicine
Introduction: Alzheimer’s disease (AD) is the most common form of dementia which burdens patients’ family and society heavily. However, no effective cure for AD was proposed.
Xin Wang, Jie Yang, Hong-Fen Jiang, Yi-Nan Yang, Mi-Na Yang, Li-Jia Ye, Miao Zhang, Zhan-Xin Zhang, Jian-Ye Dai, Dong-Qing Fei   +9 more
doaj   +1 more source

Target Identification and Validation of (+)-2-(1-Hydroxyl-4-Oxocyclohexyl) Ethyl Caffeate, an Anti-Inflammatory Natural Product

European Journal of Inflammation, 2012
(+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate (HOEC) was isolated from Incarvillea mairei var. granditlora (Wehrhahn) Grierson. The plants of the Incarvillea genus have long been used as folk medicines for the treatment of inflammation-related ...
L. Li, H-W. Zeng, F. Liu, J-G. Zhang, R-C. Yue, W-Q. Lu, X. Yuan, W-X. Dai, H. Yuan, Q-Y. Sun, J. Huang, H-L. Li, Y-S. Li, L. Shan, W-D. Zhang   +14 more
doaj   +1 more source

Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression

Heliyon, 2019
Plants of the Asteraceae family have been used in traditional medicine for centuries due to their main antimicrobial and analgesic activities. A liniment from Artemisia californica has recently been tested on patients affected by either acute pain or ...
Filomena Perri, Luca Frattaruolo, Ian Haworth, Matteo Brindisi, Asma El-magboub, Angela Ferrario, Charles Gomer, Francesca Aiello, James David Adams   +8 more
doaj   +1 more source

How different are marine microbial natural products compared to their terrestrial counterparts?

, 2021
A key challenge in natural products research is the selection of biodiversity to yield novel chemistry. Recently, marine microorganisms have become a preferred source.
Campbell, Max D, Carroll, Anthony R, Voser, Tanja M   +2 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification

Nature Communications, 2017
The biosynthesis of xiamycin, an antimicrobial bacterial indolosesquiterpenoid, involves an unusual cyclization cascade. Here, the authors characterise the XiaF enzyme, which resembles xenobiont-degrading enzymes and is responsible for a hidden indole ...
Susann Kugel, Martin Baunach, Philipp Baer, Mie Ishida-Ito, Srividhya Sundaram, Zhongli Xu, Michael Groll, Christian Hertweck   +7 more
doaj   +1 more source

Specioside (SS) & verminoside (VS) (Iridoid glycosides): isolation, characterization and comparable quantum chemical studies using density functional theory (DFT)

Heliyon, 2019
Two biologically important molecules specioside (SS) and verminoside (VS) have been isolated from the ethanolic extract of stem bark of Kigelia pinnata.
Monika Saini, Reetu Sangwan, Mohammad Faheem Khan, Ashok Kumar, Ruchi Verma, Sudha Jain   +5 more
doaj   +1 more source

The impact of natural product chemistry on medicine [PDF]

Pure and Applied Chemistry, 1967
Abstract
openaire   +1 more source

Determination of the Absolute Configuration of Natural Product Molecules Using Vibrational Circular Dichroism

, 2014
The determination of absolute configuration (AC) has been a long-standing problem in natural product chemistry. Although there are several methods capable of determining the AC of chiral molecules, some specific requirements may limit their application ...
Batista, João M. [UNESP], Vanderlan da Silva Bolzani, Da Silva Bolzani, Vanderlan [UNESP], João M. Batista   +3 more
core   +1 more source