Results 81 to 90 of about 833,393 (296)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Shenrong Guben Huanshao Wan extract reduces Aβ-induced toxicity in the Caenorhabditis elegans model of Alzheimer’s disease via SKN-1/NRF2 pathway

Pharmacological Research - Modern Chinese Medicine
Introduction: Alzheimer's disease (AD) is a complex neurodegenerative disease leading to cognitive decline and behavioral changes. With known cure often aim to alleviate symptoms, it is crucial to find novel pharmacotherapies for AD treatment.
Hui-Jie Li, Yi-Nan Yang, Xin Wang, Chun-Min Liu, Jie Yang, Hong-Fen Jiang, Guo-Lin Chai, Zhan-Xin Zhang, Fang-Di Hu, Shuang-Xi Qian, Dong-Qing Fei   +10 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Bioinspired total syntheses of natural products: a personal adventure

Beilstein Journal of Organic Chemistry
Bioinspired total synthesis represents an important concept to guide the designing of powerful synthetic strategies. Our group has a long-time interest and experience in designing synthetic strategies through analyzing the biosynthetic pathway of natural
Zhengyi Qin, Yuting Yang, Nuran Yan, Xinyu Liang, Zhiyu Zhang, Yaxuan Duan, Huilin Li, Xuegong She   +7 more
doaj   +1 more source

Application of Alginate-Based Edible Coating with Beeswax Addition on Minimally Processed Pears (Pyrus bretschneideri Rehd.)

Biology, Medicine & Natural Product Chemistry
Pears, especially after being cut, tended to experience a decline in quality and damage such as enzymatic browning, moisture loss, and texture changes.
Maftukh Zaina Luthfiyyah, Esa Ghanim Fadhallah, Novita Herdiana, Fibra Nurainy   +3 more
doaj   +1 more source

Synthesis, crystal structures, Hirshfeld surface analysis and spectroscopic studies of two Schiff bases of anisaldehyde and their urease and acetylcholinesterase inhibitory and antioxidant properties

Heliyon, 2019
The growing demand of pharmaceutical industry for more effective drugs requires new molecules with promising medicinal activities. In the present work, a natural product anisaldehyde was treated with hydrazine and 3,5-dichloroaniline to synthesize their ...
Amber Jan Muhammad, Dildar Ahmed, Sammer Yousuf, Nida Tabassum, Muhammad Tariq Qamar   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The impact of natural product chemistry on medicine [PDF]

Pure and Applied Chemistry, 1967
Abstract
openaire   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Natural products chemistry in the third millennium [PDF]

Chemistry Central Journal, 2007
The main directions of Natural Products Chemistry in the Third Millennium are summarized.
openaire   +2 more sources