Results 51 to 60 of about 1,054,829 (302)
Neurotrophic Natural Products: Chemistry and Biology [PDF]
Angewandte Chemie International Edition, 2013 AbstractNeurodegenerative diseases and spinal cord injury affect approximately 50 million people worldwide, bringing the total healthcare cost to over 600 billion dollars per year. Nervous system growth factors, that is, neurotrophins, are a potential solution to these disorders, since they could promote nerve regeneration.
Xu, Jing +2 more
openaire +4 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Formaldehyde over the central Pacific during PEM-Tropics B [PDF]
, 2001 Formaldehyde, CH2O, mixing ratios are reported for the central Pacific troposphere from a series of 41 flights, which took place in March-April 1999 as part of the NASA Pacific Exploratory Mission (PEM) -Tropics B mission.
Blake, D +9 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Smart-sized silica and brick kiln dust for stronger more sustainable white cement
Discover ChemistryHydration properties of blended cements made from white Portland cement and the waste material obtain from brick kiln called as brick kiln dust (BKD) and smart-sized silica (SSS). This research analyzes the performance of White Portland Cement (WPC) when
Shivani Pandey +4 more
doaj +1 more source
Organocatalytic synthesis of axially chiral atropisomers [PDF]
, 2017 This review summarises the recent progress made in the organocatalytic synthesis of atropisomeric compounds. Methodologies based on dynamic kinetic resolution and direct access to BINOL-like biaryls are described.
Renzi, P.
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A Convergent Total Synthesis of Balticolid
Natural Product Communications, 2017 A convergent total synthesis of the 12 membered macrolide, Balticolid ( 1 ) is described, starting from readily available homoallylic alcohol and 1,3 propane diol. The synthetic strategy involves the construction of the 12-membered lactone.
Avuluri Srilatha +2 more
doaj +1 more source
Penerapan Metode Praktikum Berbasis Bahan Alam dalam Pembelajaran Kimia untuk Meningkatkan Hasil Belajar Siswa pada Materi Reaksi Redoks [PDF]
, 2019 The purpose of this study was to determine the improvement in learning outcomes of class X students in East Halmahera 9 High School on redox reaction topic by using natural product praticum methods in chemistry learning.
Caroles, J. D. (Joice) +2 more
core
Silver and platinum-catalysed addition of O–H and N–H bonds to allenes [PDF]
, 2014 Transition-metal catalysed nucleophile addition to allenes is a very powerful tool for the synthesis of functionalised molecules containing heteroatoms, heterocycles in the intramolecular version, or allyl derivatives in the intermolecular version.
Munoz-Herranz, Maria
core +1 more source