Results 31 to 40 of about 9,230,804 (307)

Synthesis, characterization and in vitro biological evaluation of two matrine derivatives

open access: yesScientific Reports, 2018
Matrine is a traditional Chinese medicine and botanical pesticide with broad biological activities, including pharmacological and agricultural activities.
Xingan Cheng   +9 more
doaj   +1 more source

Transcription activator-like effectors from endosymbiotic bacteria control the reproduction of their fungal host

open access: yesmBio, 2023
The phytopathogenic fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans rhizoxinica) that produces a crucial virulence factor responsible for the characteristic symptoms of rice seedling blight.
Ingrid Richter   +7 more
doaj   +1 more source

Unzipping Natural Products: Improved Natural Product Structure Predictions by Ensemble Modeling and Fingerprint Matching [PDF]

open access: yes, 2018
This pre-print explores ensemble modeling of natural product targets to match chemical structures to precursors found in large open-source gene cluster repository antiSMASH. Commentary on method, effectiveness, and limitations are enclosed.
Yohann, Potier   +5 more
core   +1 more source

The effect of mixing and consistency on cellulose cationization

open access: yesHeliyon, 2019
Traditional chemical modifications of cellulose are usually done at low or medium consistencies. Processing at high solids content is expected to provide a leap forward in reduction of manufacturing costs such as minimization of chemical use, energy ...
Pia Willberg-Keyriläinen   +4 more
doaj   +1 more source

Functionalized Nitroimidazole Scaffold Construction and Their Pharmaceutical Applications: A 1950–2021 Comprehensive Overview

open access: yesPharmaceuticals, 2022
Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with ...
Ria Gupta   +5 more
doaj   +1 more source

Xanthine scaffold: scope and potential in drug development

open access: yesHeliyon, 2018
Medicinal plants have been the basis for discovery of various important marketed drugs. Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline, theobromine, etc) are abode in tea, coffee, cocoa, chocolate etc.
Nivedita Singh   +3 more
doaj   +1 more source

Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine

open access: yesNature Communications, 2022
The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. Herein, the authors report the NMR solution structures of a bulge-containing KRAS-G4 that bound to two small molecules ...
Kai-Bo Wang   +10 more
doaj   +1 more source

The crystal structure of a matrine derivative: 41S,7aS,12S,13aR,13bR)-12-(4-methylpiperazin-1-yl)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one, C20H34N4O

open access: yesZeitschrift für Kristallographie - New Crystal Structures, 2018
C20H34N4O, triclinic, P1 (no. 1), a = 7.8545(6) Å, b = 10.8802(9) Å, c = 12.3714(9) Å, α = 73.200(7)°, β = 75.372(6)°, γ = 71.091(7)°, V = 942.65(13) Å3, Z = 2, Rgt(F) = 0.0591, wRref(F2) = 0.1641, T = 293(2) K.
Cheng Xing-An   +5 more
doaj   +1 more source

Phenolic profiling and therapeutic potential of local flora of Azad Kashmir; In vitro enzyme inhibition and antioxidant

open access: yesOpen Chemistry, 2017
The current study supports the phytochemical screening, evaluation of antioxidant and enzyme inhibition potential and correlations between antioxidant activities and phenolics of Rumex dentatus (Family: Polygonaceae), Mentha spicata (Family: Lamiaceae ...
Raza Muhammad Asam   +5 more
doaj   +1 more source

Optimization of choline chloride-glycerol based natural deep eutectic solvent for extraction bioactive substances from Cinnamomum burmannii barks and Caesalpinia sappan heartwoods

open access: yesHeliyon, 2019
Indonesian cassia (Cinnamomum burmannii Blume) is commonly used as a condiment. It reportedly contains a number of major phytochemical constituents such as trans-cinnamaldehyde and coumarin. Sappan wood (Caesalpinia sappan) is a native plant of Southeast
Aditya Sindu Sakti   +2 more
doaj   +1 more source

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