Results 21 to 30 of about 833,393 (296)
Biochimica et Biophysica Acta - General Subjects, 2017 The oceans are a uniquely rich source of bioactive metabolites, of which sponges have been shown to be among the most prolific producers of diverse bioactive secondary metabolites with valuable therapeutic potential.
Vedanjali Gogineni, M. Hamann
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Analysis of major carotenoids and fatty acid composition of freshwater microalgae
Heliyon, 2019 Considering the nutraceutical properties, the high commercial value from pigments and essential lipids and the environmental sustainability, the purposes of this study were to assess the major carotenoids and fatty acids composition of nine microalgae ...
Aline Terra Soares +3 more
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Pharmaceuticals, 2022 Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with ...
Ria Gupta +5 more
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, 2016 The discovery of new natural products from fungi isolated from substrata in marine environment has increased dramatically over the last few decades, cumulating in over 1000 new metabolites.
K. Pang +9 more
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Synthesis, characterization and in vitro biological evaluation of two matrine derivatives
Scientific Reports, 2018 Matrine is a traditional Chinese medicine and botanical pesticide with broad biological activities, including pharmacological and agricultural activities.
Xingan Cheng +9 more
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Nature Communications, 2022 The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. Herein, the authors report the NMR solution structures of a bulge-containing KRAS-G4 that bound to two small molecules ...
Kai-Bo Wang +10 more
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mBio, 2023 The phytopathogenic fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans rhizoxinica) that produces a crucial virulence factor responsible for the characteristic symptoms of rice seedling blight.
Ingrid Richter +7 more
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The effect of mixing and consistency on cellulose cationization
Heliyon, 2019 Traditional chemical modifications of cellulose are usually done at low or medium consistencies. Processing at high solids content is expected to provide a leap forward in reduction of manufacturing costs such as minimization of chemical use, energy ...
Pia Willberg-Keyriläinen +4 more
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Xanthine scaffold: scope and potential in drug development
Heliyon, 2018 Medicinal plants have been the basis for discovery of various important marketed drugs. Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline, theobromine, etc) are abode in tea, coffee, cocoa, chocolate etc.
Nivedita Singh +3 more
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Journal of Medicinal ChemistryDrug discovery, a multifaceted process from compound identification to regulatory approval, historically plagued by inefficiencies and time lags due to limited data utilization, now faces urgent demands for accelerated lead compound identification ...
Amit Gangwal, Antonio Lavecchia
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