Results 11 to 20 of about 1,054,829 (302)

Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods [PDF]

, 2015
Flow chemistry is widely used nowadays in synthetic chemistry and has increasingly been applied to complex natural product synthesis. However, to date flow chemistry has not found a place in the area of biomimetic synthesis.
Kamptmann, SB, Ley, SV
core   +1 more source

Click-based synthesis and proteomic profiling of lipstatin analogues [PDF]

, 2010
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved
Adam, Brik, Browne, Carpita, Carvalho, Cheng, Evans, Garcia-Fandino, Guerciolini, Kai Liu, Kalesh, Kalesh, Keck, Knowles, Knowles, Kridel, Kridel, Little, Little, Ma, Markus R. Wenk, Martin J. Lear, Menendez, Menendez, Menendez, Mori, Morten Meldal, Mun H. Ngai, Pemble, Peng-Yu Yang, Pommier, Richardson, Shao Q. Yao, Sletten, Srinivasan, Srinivasan, Uttamchandani, Yang, Yuan Shen   +38 more
core   +1 more source

Sonogashira diversification of unprotected halotryptophans, halotryptophan containing tripeptides; and generation of a new to nature bromo-natural product and its diversification in water [PDF]

, 2017
The blending together of synthetic chemistry with natural product biosynthesis represents a potentially powerful approach to synthesis; to enable this, further synthetic tools and methodologies are needed.
Abou Fayad, A, Bown, R T, Cartmell, C, Corr, M J, Goss, R J M, Poirot, P, Pubill-Ulldemolins, C, Sharma, S V, Smith, D R M   +8 more
core   +2 more sources

The stellar halo of the Galaxy [PDF]

, 2008
Stellar halos may hold some of the best preserved fossils of the formation history of galaxies. They are a natural product of the merging processes that probably take place during the assembly of a galaxy, and hence may well be the most ubiquitous ...
A Frebel, A Frebel, A Gould, A Gould, A Heger, A Helmi, A Helmi, A Helmi, A Helmi, A Helmi, A Helmi, A Helmi, A Helmi, A Helmi, A Helmi, A Klypin, A Klypin, A Koch, A McWilliam, A Moitinho, A Sarajedini, AA Kepley, AC Layden, AC Layden, AC Robin, AC Robin, AD Mackey, AJ Benson, AK Vivas, AK Vivas, Amina Helmi, AP Digby, AR Zentner, AS Font, AV Kravtsov, AV Kravtsov, AW McConnachie, B Chaboyer, B Chen, B Famaey, B Fuchs, B Letarte, B Moore, B Moore, B Paczynski, B Yanny, B Yanny, BMS Hansen, BW Carney, C Chiappini, C Flynn, C Sneden, C Travaglio, CB Brook, CB Brook, CJ Grillmair, CJ Grillmair, CJ Grillmair, CJ Grillmair, CS Frenk, D Carollo, D Geisler, D Lynden-Bell, D Martínez-Delgado, D Martínez-Delgado, D Martínez-Delgado, D Minniti, DI Casetti-Dinescu, DI Dinescu, DJ Lemon, DN Spergel, DR Law, E Bica, E Carretta, E Sirko, E Tolstoy, E Tolstoy, F De Angeli, F Hammer, F Matteucci, F Stoehr, FDA Hartwick, G Battaglia, G Battaglia, G Cescutti, G Gilmore, G Gilmore, G Gilmore, G Kauffmann, G Piotto, GM De Silva, GM Seabroke, GW Preston, H Baumgardt, H Shapley, H Umeda, HJ Newberg, HJ Newberg, HJ Newberg, HJ Rocha-Pinto, HL Morrison, HL Morrison, HL Morrison, II Ivans, J Binney, J Bland-Hawthorn, J Diemand, J Mould, J Peñarrubia, J Silk, J Sommer-Larsen, J Sommer-Larsen, J Tumlinson, JC Kapteyn, JC Wheeler, JD Simon, JF Navarro, JF Navarro, JG Cohen, JK Adelman-McCarthy, JN Bahcall, JP Fulbright, JS Bullock, JS Bullock, JS Bullock, JS Kalirai, K Bekki, KA Venn, KC Freeman, KM Ashman, KU Ratnatunga, KV Johnston, KV Johnston, KV Johnston, KV Johnston, L Clewley, L Clewley, L Gao, L Mayer, L Searle, LV Sales, M Arnould, M Bellazzini, M Chiba, M Chiba, M Chiba, M Fellhauer, M Juric, M Mateo, M Metz, M Mouhcine, M Mouhcine, M Mouhcine, M Odenkirchen, M Samland, M Schmidt, M Shetrone, M Shetrone, M Steinmetz, M Steinmetz, M Unavane, M-M Mac Low, MA Gómez-Flechoso, MAC Perryman, MC Smith, MG Abadi, MG Abadi, MH Siegel, MH Siegel, MI Wilkinson, ML Mateo, N Libeskind, NB Suntzeff, NC Hambly, NF Martin, NF Martin, NY Gnedin, OJ Eggen, P Côté, P François, P Harding, P Kroupa, PB Stetson, PB Stetson, PD Sackett, PE Nissen, PE Nissen, PJ Quinn, PS Barklem, R Cayrel, R Cayrel, R Ibata, R Ibata, R Ibata, R Ibata, R Schneider, RC Dohm-Palmer, RP Marel van der, RP Marel van der, RS Somerville, S Duffau, S Lucatello, S Phleps, S Piatek, S Salvadori, S Torres, S Zibetti, SC Chapman, SDM White, SDM White, SG Ryan, SR Majewski, SR Majewski, SR Majewski, SR Majewski, T Abel, TC Beers, TC Beers, TD Kinman, TD Kinman, TM Brown, V Belokurov, V Belokurov, V Belokurov, V Belokurov, V Belokurov, V Bromm, V Hill, V Springel, W Dehnen, WE Harris, X Kang, Y Momany, Y Momany, Y Xu, Y Xu, Y-W Lee, YS Li, YW Lee, Z Zheng, Ž Ivezić   +240 more
core   +3 more sources

Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin [PDF]

, 2015
Previous studies on the natural product chlorofusin have shown that the full peptide and azaphilone structure are required for inhibition of the interaction between MDM2 and p53.
Clark, Clark, Clark, Desai, Duncan, Ewan Raffel, Howell, Jordann C. Ramoutar, Kerrie D. Turner, Knight, Kolb, Lee, Lesley A. Howell, Li, Malkinson, Marco M.D. Cominetti, Maria A. O’Connell, Mark Searcey, Mori, Qian, Qiu, Qiu, Sang, Sarah A. Goffin, Woon   +24 more
core   +1 more source

Investigating the Initial Steps in the Biosynthesis of Cyanobacterial Sunscreen Scytonemin [PDF]

, 2014
The cyanobacterial natural product scytonemin (1) functions as a sunscreen, absorbing harmful UV-A radiation. Using information from a recently identified gene cluster, we propose a biosynthetic route to this pigment.
Balskus, Emily Patricia, Walsh, Christopher T.   +1 more
core   +1 more source

Functionalized Nitroimidazole Scaffold Construction and Their Pharmaceutical Applications: A 1950–2021 Comprehensive Overview

Pharmaceuticals, 2022
Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with ...
Ria Gupta, Sumit Sharma, Rohit Singh, Ram A. Vishwakarma, Serge Mignani, Parvinder Pal Singh   +5 more
doaj   +1 more source

Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering [PDF]

, 2016
Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions.
Andersen, Mikael Rørdam, Hoof, Jakob Blæsbjerg, Larsen, Thomas Ostenfeld, Mortensen, Uffe Hasbro, Nielsen, Maria Lund, Petersen, Lene Maj, Petersen, Thomas Isbrandt   +6 more
core   +2 more sources

Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine

Nature Communications, 2022
The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. Herein, the authors report the NMR solution structures of a bulge-containing KRAS-G4 that bound to two small molecules ...
Kai-Bo Wang, Yushuang Liu, Jinzhu Li, Chengmei Xiao, Yingying Wang, Wei Gu, Yipu Li, Yuan-Zheng Xia, Tingdong Yan, Ming-Hua Yang, Ling-Yi Kong   +10 more
doaj   +1 more source

Transcription activator-like effectors from endosymbiotic bacteria control the reproduction of their fungal host

mBio, 2023
The phytopathogenic fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans rhizoxinica) that produces a crucial virulence factor responsible for the characteristic symptoms of rice seedling blight.
Ingrid Richter, Zerrin Uzum, Philipp Wein, Evelyn M. Molloy, Nadine Moebius, Timothy P. Stinear, Sacha J. Pidot, Christian Hertweck   +7 more
doaj   +1 more source