Click Chemistry in Natural Product Modification [PDF]
Frontiers in Chemistry, 2021 Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now.
Xiang Zhang +5 more
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Antibiofilm and antibacterial activities of lupinifolin in combination with protein synthesis inhibitors against methicillin-resistant Staphylococcus aureus [PDF]
Journal of HerbMed Pharmacology, 2023 Introduction: Methicillin-resistant Staphylococcus aureus (MRSA)-derived biofilm formation is a crucial virulence factor, which essentially contributes to therapeutic challenges.
Parichart Kwaengmuang +4 more
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Streptomyces cell-free systems for natural product discovery and engineering [PDF]
, 2022 Streptomyces bacteria are a major microbial source of natural products, which are encoded within so-called biosynthetic gene clusters (BGCs). This highlight discusses the emergence of native Streptomyces cell-free systems as a new tool to accelerate the ...
Lai, H-E +7 more
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Strategic Enzymatic Transformations in Modern Natural Product Synthesis [PDF]
, 2022 Enzymes continue to gain recognition as valuable tools in synthetic chemistry as they enable transformations, which elude conventional organochemical approaches.
Felix, Kaspar, Anett, Schallmey
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The chemistry of isoindole natural products [PDF]
Beilstein Journal of Organic Chemistry, 2013 This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type ...
Klaus Speck, Thomas Magauer
openaire +3 more sources
Bacterial natural product discovery by heterologous expression [PDF]
, 2023 Natural products have found important applications in the pharmaceutical and agricultural sectors. In bacteria, the genes that encode the biosynthesis of natural products are often colocalized in the genome, forming biosynthetic gene clusters.
Adjo, Kadjo, Alessandra, Eustaquio
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Natural Product Scores and Fingerprints Extracted from Artificial Neural Networks. [PDF]
, 2021 Due to their desirable properties, natural products are an important ligand class for medicinal chemists. However, due to their structural distinctiveness, traditional cheminformatic approaches, like ligand-based virtual screening, often perform worse ...
Joana, Massa +2 more
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Limonene as natural product extraction solvent [PDF]
, 2023 First reported in 2004, and subsequently advanced by Chemat’s and other research teams in the following two decades, the use of d-limonene as natural product extraction solvent offers multiple benefits that go beyond its environmentally benign nature ...
Mario, Pagliaro +2 more
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Natural product-based PROteolysis TArgeting Chimeras (PROTACs)
, 2022 Covering: upto 2022 Natural products have an embedded recognition of protein surfaces. They possess this property as they are produced by biosynthetic enzymes and are substrates for one or more enzymes in the biosynthetic pathway. The inherent advantages,
Liu, Miaomiao +2 more
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68 million natural product-like compound database generated via molecular language processing [PDF]
, 2023 Natural products are a rich resource of bioactive compounds for valuable applications across multiple fields such as food, agriculture, medicine. For natural product discovery, high throughput in silico screening offers a cost-effective alternative to ...
Shi Jun, Ang +4 more
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