Results 181 to 190 of about 12,894,217 (402)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Modeling the Impact of New Information on Consumer Preferences for Specialty Meat Products [PDF]

As the demand for organic and natural food grows in the U.S., studies show that consumers would and do pay more for these foods than their traditional counterparts.
Curtis, Kynda R., Moeltner, Klaus, Wang, Xi   +2 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Electrocardiographic recording (ECG) of hatchling females and males of scorpion mud turtle (Kinosternon scorpioides) subjected to restraint stress

Discover Animals
The species Kinosternon scorpioides (scorpion mud turtle) has potential for commercial farming in captivity. Restraint is a stressful factor that can cause fatal reactions. However, research on stress in Muçuãs is scarce.
Brenda Stefany dos Santos Braga, Deise de Lima Cardoso, Daniella Bastos de Araújo, Clarissa Araújo da Paz, Luciana Eiró-Quirino, Thaysa de Sousa Reis, Gabriela Brito Barbosa, Luana Vasconcelos de Souza, Laís Helena Baptista Amóras, Lucas Lima da Rocha, Maria Klara Otake Hamoy, José Ribamar Felipe Marques, Diva Anelie de Araújo Guimarães, Moises Hamoy   +13 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Aerobic oxidative bromination and iodination enabled by alloxan and ascorbic acid to mimic flavin-dependent halogenases

Nature Communications
The fundamentally significant halogenation processes in organic synthesis heavily depend on the use of hazardous and toxic elemental halogens directly or indirectly, inevitably increasing environmental burden and leading to various production problems ...
Shiqi Zhang, Guang-xun Li, Dongmei Fang, Xia Zhang, Shangjing Chen, Xin Cui, Zhuo Tang   +6 more
doaj   +1 more source

The structural modification of natural products for novel drug discovery

, 2016
Hong Yao, Junkai Liu, Shengtao Xu, Zheying Zhu, Jinyi Xu   +4 more
openalex   +2 more sources

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

Nature Biotechnology, 2016
Mingxun Wang, Jeremy J. Carver, Vanessa V. Phelan, Laura M. Sanchez, Neha Garg, Yao Peng, Don D. Nguyen, J. Watrous, Clifford A. Kapono, Tal Luzzatto-Knaan, Carla Porto, Amina Bouslimani, A. Melnik, Michael J. Meehan, Wei-Ting Liu, M. Crüsemann, Paul D. Boudreau, E. Esquenazi, Mario Sandoval-Calderón, R. Kersten, L. Pace, R. Quinn, Katherine R. Duncan, Cheng-Chih Hsu, D. Floros, R. Gavilán, Karin Kleigrewe, T. Northen, R. Dutton, D. Parrot, Erin E. Carlson, B. Aigle, C. F. Michelsen, L. Jelsbak, Christian Sohlenkamp, P. Pevzner, A. Edlund, J. McLean, J. Piel, B. Murphy, L. Gerwick, C. Liaw, Yu-Liang Yang, H. Humpf, M. Maansson, R. Keyzers, A. Sims, Andrew R. Johnson, A. Sidebottom, Brian E. Sedio, Andreas K. Klitgaard, Charles B. Larson, Cristopher A Boya P, Daniel Torres-Mendoza, D. Gonzalez, D. Silva, L. M. Marques, D. Demarque, E. Pociūtė, E. O’Neill, Enora Briand, Eric J. N. Helfrich, Eve A Granatosky, E. Glukhov, Florian Ryffel, H. Houson, H. Mohimani, Jenan J. Kharbush, Yi Zeng, J. Vorholt, Kenji L. Kurita, Pep Charusanti, K. McPhail, K. Nielsen, L. Vuong, Maryam Elfeki, Matthew F. Traxler, Niclas Engene, Nobuhiro Koyama, Oliver B. Vining, R. Baric, Ricardo R. Silva, Samantha J. Mascuch, S. Tomasi, Stefan Jenkins, V. Macherla, Thomas Hoffman, V. Agarwal, P. Williams, Jingqui Dai, R. Neupane, Joshua R. Gurr, A. M. C. Rodriguez, Anne Lamsa, Chen Zhang, Kathleen Dorrestein, B. Duggan, J. Almaliti, Pierre-Marie Allard, P. Phapale, Louis-Félix Nothias, T. Alexandrov, M. Litaudon, J. Wolfender, J. Kyle, T. Metz, Tyler Peryea, Dac-Trung Nguyen, Danielle Vanleer, P. Shinn, A. Jadhav, R. Müller, K. Waters, Wenyuan Shi, Xueting Liu, Lixin Zhang, R. Knight, P. Jensen, B. Palsson, K. Pogliano, Roger G. Linington, Marcelino Gutiérrez, N. Lopes, W. Gerwick, B. Moore, P. Dorrestein, N. Bandeira   +126 more
semanticscholar   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Organic substances against Monilia laxa on apricot – in-vitro and on-farm experiments [PDF]

, 2019
Natural substances against Monilia laxa were onfarm and in-vitro tested. According to on-farm tests, some products reached interesting efficacies.
Christen, Danilo, Del Cueto, Jorge, Lebleu, Flore, Stefani, Patrick   +3 more
core