Results 111 to 120 of about 7,916,773 (303)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Discrimination of Klebsiella pneumoniae and Klebsiella quasipneumoniae by MALDI‐TOF Mass Spectrometry Coupled With Machine Learning

MicrobiologyOpen
Klebsiella species, including Klebsiella pneumoniae and Klebsiella quasipneumoniae, present significant challenges in clinical microbiology due to their genetic similarity, which complicates accurate species identification using established methods ...
Mari Nishikawa, Wenhao Tang, Markus Kostrzewa, Jonah Rodgus, Frances Davies, Yi Liu, Elita Jauneikaite, Gerald Larrouy‐Maumus   +7 more
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Natural resistance of tomato plants to Tomato yellow leaf curl virus. [PDF]

Front Plant Sci, 2022
H El-Sappah A, Qi S, A Soaud S, Huang Q, M Saleh A, A S Abourehab M, Wan L, Cheng GT, Liu J, Ihtisham M, Noor Z, Rouf Mir R, Zhao X, Yan K, Abbas M, Li J.   +15 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

A general guide to the American Museum of Natural History. (Guide leaflet, no. 13)

, 1904
54 p. : ill., map ; 25 cm.Supplement to: American Museum journal, v. 4, no. 1, Jan. 1904. Subsequently published as: General guide to the exhibition halls of the American Museum of Natural History, [1st ed.] (1911)
American Museum of Natural History.
core   +1 more source

Serum iron levels in tuberculosis patients and household contacts and its association with natural resistance-associated macrophage protein 1 polymorphism and expression. [PDF]

Clin Respir J, 2023
Waworuntu W, Tanoerahardjo FS, Mallongi A, Ahmad A, Amin M, Djaharuddin I, Bukhari A, Tabri NA, Bahar B, Hidayah N, Halik H, Massi MN.   +11 more
europepmc   +1 more source

Rv3400 is a phosphoglucomutase required for trehalose metabolism in Mycobacterium tuberculosis

Journal of Bacteriology
Mycobacterium tuberculosis (Mtb) causes over 1 million deaths from tuberculosis (TB) every year and remains a major burden on human health. Reducing the deadly impact of TB requires a better understanding of the strategies used by M.
Yi Liu, Nadine Ruecker, Valwynne Faulkner, Kavitha Rachineni, Nada Al-Saffar, Elisabeth Oskoui, Larissa Zarate Garcia, Jessica Emma Rowley, Pablo Villacampa Teixeira, Tiago R. D. Costa, Eachan Johnson, Brian D. Robertson, Sabine Ehrt, Gerald Larrouy-Maumus   +13 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source