Results 31 to 40 of about 2,859,789 (309)

Native Plasmid-Encoded Mercury Resistance Genes Are Functional and Demonstrate Natural Transformation in Environmental Bacterial Isolates. [PDF]

, 2019
Plasmid-mediated horizontal gene transfer (HGT) is a major driver of genetic diversity in bacteria. We experimentally validated the function of a putative mercury resistance operon present on an abundant 8-kbp native plasmid found in groundwater samples ...
Carlson, Hans K, Deutschbauer, Adam M, Kothari, Ankita, Mukhopadhyay, Aindrila, Soneja, Drishti, Tang, Albert   +5 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. [PDF]

, 2018
Bioactive natural products have evolved to inhibit specific cellular targets and have served as lead molecules for health and agricultural applications for the past century1-3.
Bat-Erdene, Undramaa, Gan, Jianhua, Jacobsen, Steven E, Liu, Qikun, Nguyen, Calvin, Tang, Yi, Yan, Yan, Yuan, Shuguang, Zang, Xin, Zhou, Jiahai   +9 more
core  

Extensive structure‐activity relationship study of albicidin’s C‐terminal dipeptidic p‐aminobenzoic acid moiety [PDF]

, 2019
Albicidin is a recently described natural product that strongly inhibits bacterial DNA gyrase. The pronounced activity, particularly against Gram‐negative bacteria, turns it into a promising lead structure for an antibacterial drug.
Behroz, Iraj, Durkin, Patrick, Grätz, Stefan, Rostock, Lida, Seidel, Maria, Spinczyk, Marcello, Süßmuth, Roderich D., Weston, John B.   +7 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

An Assessment of the Viability of Lytic Phages and Their Potency against Multidrug Resistant Escherichia coli O177 Strains under Simulated Rumen Fermentation Conditions

Antibiotics, 2021
Preslaughter starvation and subacute ruminal acidosis in cattle are known to promote ruminal proliferation of atypical enteropathogenic Escherichia coli strains, thereby increasing the risk of meat and milk contamination. Using bacteriophages (henceforth
Peter Kotsoana Montso, Caven Mguvane Mnisi, Collins Njie Ateba, Victor Mlambo   +3 more
doaj   +1 more source

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. [PDF]

, 2015
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin,
Carelli, Jordan D, Jain, Rishi K, Merrick, William C, Miller, Howard R, Ross, Nathan T, Sethofer, Steven G, Simard, Jillian L, Smith, Geoffrey A, Taunton, Jack   +8 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals the transcriptome profile of Microtus fortis immune cells during the early phase of infection with Schistosoma japonicum

Frontiers in Cellular and Infection Microbiology
IntroductionThe reed vole, Microtus fortis, is the only known natural non-permissive mammalian host of Schistosoma japonicum. However, the molecular mechanisms underlying this resistance have not been fully understood.MethodsWe performed single-cell RNA ...
Nouhoum Dibo, Nouhoum Dibo, Zhijun Zhou, Xianshu Liu, Xianshu Liu, Zhuolin Li, Zhuolin Li, Shukun Zhong, Shukun Zhong, Jiajing Zhang, Jiajing Zhang, Huilan Wang, Huilan Wang, Huilan Wang, Bo Li, Bo Li, Bo Li, Xiaohui Yang, Yuehui Li, Xiang Wu, Xiang Wu, Xiang Wu, Shuaiqin Huang, Shuaiqin Huang, Shuaiqin Huang   +24 more
doaj   +1 more source

Exploring chemical diversity in Glycine max cultivars: A multivariate approach in the search for bioactive compounds against Spodoptera cosmioides

Frontiers in Plant Science, 2022
Soybean crop is regulated by abiotic and biotic stresses with great potential in reducing grain yield and quality. The selection of resistant cultivars is a promising approach for mitigating these damages. We evaluated the chemical profile of Glycine max
Maria Clara Santana Aguiar, Marcelo Mueller de Freitas, Carlos Alessandro de Freitas, Arlindo Leal Boiça Júnior, Renato Lajarim Carneiro, Maria Fátima das Graças Fernandes da Silva, João Batista Fernandes, Moacir Rossi Forim   +7 more
doaj   +1 more source