Results 41 to 50 of about 7,916,773 (303)
Frontiers in Immunology, 2020 IntroductionThe HIV-exposed seronegative (HESN) status is for individuals who remain seronegative despite repeated exposure to HIV. One of the main cohorts within this group is men who have sex with men (MSM).
Lizdany Flórez-Álvarez +8 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Final report to the Oregon Watershed Enhancement Board.KEYWORDS: Oregon, Willamette Valley Ecoregion, Benton County (Oregon), Dams, North Pacific coast, Tillamook County (Oregon), Aquatic resources, Management, Lincoln County (Oregon), Polk County ...
Oregon State University. Institute for Natural Resources
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The nature of the increased peripheral resistance in hypertension∗ [PDF]
The American Journal of Cardiology, 1960 Abstract Studies on hypertension in both human beings and animals have shown an increased response to vasopressor and vasodepressor agents. This increased reactivity, as well as the incompleteness of vasodilatation by large doses of vasodepressor agents, is believed to be due to structural changes in the vascular tree.
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Antibiotics, 2021 Preslaughter starvation and subacute ruminal acidosis in cattle are known to promote ruminal proliferation of atypical enteropathogenic Escherichia coli strains, thereby increasing the risk of meat and milk contamination. Using bacteriophages (henceforth
Peter Kotsoana Montso +3 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Antimicrobial Resistance in the Netherlands: A Natural Experiment? [PDF]
Frontiers in Public Health, 2014 Use and misuse of antimicrobial agents lead to antimicrobial resistance. This is well-known, as it is equally well known that restrictive use results in lower resistance rates. However, how powerful restrictive use is in minimizing the rise of antimicrobial resistance is not very well documented.
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ЕСТЕСТВЕННАЯ РЕЗИСТЕНТНОСТЬ СВИНЕЙ С РАЗЛИЧНОЙ СТРЕСС-РЕАКТИВНОСТЬЮ
Ветеринарная патология, 2011 Comparative characteristics of natural resistance indices of pigs of Steppe and Don meat types, Large White breed and their hybrids depending on stress-reactivity are given.
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