Results 81 to 90 of about 2,859,789 (309)

The integrated concept of disease resistance; a new view including horizontal and vertical resistance in plants [PDF]

open access: yes, 1977
Horizontal, uniform, race-non-specific or stable resistance can be discerned according to Van der Plank, from vertical, differential, race-specific or unstable resistance by a test in which a number of host genotypes (cultivars or clones) are tested ...
Parlevliet, J.E., Zadoks, J.C.
core   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome [PDF]

open access: yes, 2013
Natural variation for LPS-induced lethal inflammation in mice is useful for identifying new genes that regulate sepsis, which could form the basis for novel therapies for systemic inflammation in humans.
Beaulieu E   +12 more
core   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

СЕЗОННАЯ ДИНАМИКА ФАКТОРОВ ЕСТЕСТВЕННОЙ РЕЗИСТЕНТНОСТИ

open access: yesВетеринарная патология, 2011
The evaluation of season dynamics of natural resistance factors is conducted.

doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

РЕЗИСТЕНТНОСТЬ ПОМЕСНЫХ ПОРОСЯТ РАЗЛИЧНЫХ ГЕНОТИПОВ ПО ГЕНУ RYR-1

open access: yesВетеринарная патология, 2012
authors define level of natural resistance of pigs of different genotypes on gene RYR-1 at carrying out of two - and three-pedigree industrial crossing.

doaj  

Are zooplankton invasions in constructed waters facilitated by simple communities? [PDF]

open access: yes, 2010
The invasion of non-indigenous species is considered to be one of the leading causes of biodiversity loss globally. My research aimed to determine if constructed water bodies (e.g., water supply reservoirs, dams and ponds) were invaded by zooplankton ...
Parkes, Samantha Maree
core   +1 more source

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