Results 61 to 70 of about 5,946,843 (301)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Women’s Rights in John Minter Morgan’s Hampden in the Nineteenth Century (1834)
Caliban: French Journal of English Studies, 2019 Alors que Mary Wollstonecraft et William Godwin, radicaux jacobins de la fin du XVIIIe siècle, avaient pris position pour l’extension de l’éducation et des droits civils aux femmes, le début du XIXe siècle vit au contraire leurs droits limités.
Alexandra Sippel
doaj +1 more source
Rights of Nature and the Antarctic: An Introduction
The Polar JournalThis publication provides an introduction to The Polar Journal's Special Issue on Rights of Nature and the Antarctic. The Special Issue aims to advance the scholarly discussion on Antarctic RoN. The authors discuss the concept of RoN and its relevance for the Antarctic, the interconnections between RoN and the recognition of Antarctica’s intrinsic ...
Yousra Makanse +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
ARE HUMAN RIGHTS OF RELIGIOUS ORIGIN?
Sur: International Journal on Human Rights, 2019 Are human rights codified in the late eighteenth century by natural rights of divine or philosophical origin? This question haunted Western political thought throughout the nineteenth and twentieth centuries.
Valentine Zuber
doaj
Human Rights Against Human Rights: From Emancipation to Domination [PDF]
پژوهشنامه حقوق اسلامی ∴ Introduction ∴ The modern era is characterized by the unprecedented ascendance of human rights as a dominant global discourse. Human rights have not only supplanted other normative systems but have also evolved into what can be described as a ...
Ali Saberi Tavallaei
doaj +1 more source
International Journal of Human Rights, 2019 This article assess the degree of cross-fertilisation of international human rights and environmental law on fair and equitable benefit-sharing in relation to the human rights of indigenous peoples and local communities over natural resources.
Elisa Morgera
semanticscholar +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source