Results 41 to 50 of about 77,443 (304)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Beginning again. The task of design research

open access: yesJoelho, 2013
Among architects and educators today the proposal for design research is generally understood as follows: the design of buildings is not only a professional practice but also a form of inquiry, a member of the growing family of research ...
David Leatherbarrow
doaj   +1 more source

Scientometrics of Scientometrics Based on Web of Science Core Collection Data between 1992 and 2020

open access: yesInformation, 2023
Scientometrics is a quantitative and statistical approach that analyzes research on certain themes. It originated from information/library science but has been applied in various disciplines, including information science, library science, natural ...
Yang Liu, Hailong He
doaj   +1 more source

PROFESSIONAL COMPETENCES OF NATURAL SCIENCE TEACHER DISCIPLINES IN THE MODERN SCHOOL

open access: yesТHE SOURCES OF PEDAGOGICAL SKILLS, 2019
The current situation in education reflects the real picture of the transition to a post-industrial society, the value of which is competence and competence. Until recently, the concept of competence and competence was associated with higher professional education, where specific methods of training specialists were born: task, project, contextual, and
MARTSENYUK, T., SHCHERBAN, M.
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Features of the study of natural science disciplines bachelors with psychology [PDF]

open access: yes, 2017
У статті розглядаються дисципліни природничого циклу в професійній підготовці бакалаврів з психології. Детально розглянуто, якими особливостями володіють природничі дисципліни в процесі навчання бакалаврів з психології.
Хавіна, Ірина Валер'ївна   +1 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Diversifying student demographics in forestry and related natural resources disciplines

open access: yes, 2015
Diversification of student demographics in forestry and related natural resources (NR) disciplines is required if the profession is to get to a point where its diversity is reflective of society as a whole and is to help change culture and enable new ...
Sharik, Terry
core   +1 more source

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