Results 61 to 70 of about 77,443 (304)

Expanding new niche for DRJ: Evolution of an institutional scholarly publication

Davao Research Journal, 2015
The Davao Journal (DRJ) is in a transition period of expansion in its scope, types of manuscript accepted, manuscript preparation, and ethical standards. This expansion aims to cater more diverse manuscripts in various disciplines both in Natural Science
Emily Antonio
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Exploring Natural and Social Scientists' Views of Nature of Science

, 2014
Science education researchers recently turned their attention to exploring views about nature of science (NOS). A large body of research indicates that both students and teachers have many naive views about the NOS. Unfortunately, less attention has been
Ertas, Ozge, Cakici, Yilmaz, Bayir, Eylem   +2 more
core   +1 more source

Implementation of the eco-oriented component in the disciplines of the natural sciences and humanities cycle

Management of Education, 2022
Ценностное, нравственное отношение к природе, по нашему заключению, предполагает, что природный объект или явление обладает определенными свойствами, которые позволяют признать его полезность или вредность. Однако не все, что полезно в определенный момент отдельному индивиду, одновременно является благом вообще и пользой для всех. Утилитарное отношение
openaire   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Women in life science disciplines

, 2002
The breakdown of the life science disciplines within the College of Life Sciences and Agriculture at the University of New Hampshire allowed us to establish the graduation patterns of men and women within the respective disciplines.
Douce, Lorraine D., Bedker, Patricia A., Sparrow, John E.   +2 more
core  

Features of Realization of Interdisciplinary Integration of Natural-Science and Technical Blocks of Disciplines

Mediterranean Journal of Social Sciences, 2015
In work experience, the realization of interdisciplinary integration of disciplines of natural science and technical blocks when training graduates of the construction direction in technical college is considered. Formation of professional competence of the Bachelor is one of the strategic tasks of higher education institution that decision is possible
D.K. Afanasova, Z.Z. Utyaganova
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Application of information technologies to improve the quality of mathematical trainingo teachers of natural-science disciplines

, 2020
© 2018 Authors. The actuality of the problem stated in the article is due to the fact that the level of professional competence of future teachers of the natural- science subjects largely depends on the quality of mathematical training, which is largely ...

core