Results 81 to 90 of about 728,426 (302)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cellular Automata Applications in Shortest Path Problem

, 2017
Cellular Automata (CAs) are computational models that can capture the essential features of systems in which global behavior emerges from the collective effect of simple components, which interact locally.
A Macwan, A Nash, AI Adamatzky, Anastasios Tsiftsis, C Nieto-Granda, C. Hochberger, C. Y. Lee, Christian Hochberger, D Ferguson, DB Johnson, EW Dijkstra, Fabio M. Marchese, G Ch Sirakoulis, G Ch Sirakoulis, George S. Fishman, H Beigy, Hong Qu, Ioakeim G. Georgoudas, J Li, J Neumann Von, J-H Liang, K Nagel, K. Ioannidis, Konstantinos Ioannidis, Lazaros Nalpantidis, M Defoort, M.A. Porta Garcia, M.G. Kechaidou, Michail-Antisthenis I Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Michail-Antisthenis I. Tsompanas, Nikolaos Dourvas, Nikolaos I. Dourvas, Nikolaos I. Dourvas, O Montiel, PG Tzionas, Q Sun, RW Floyd, S Liu, S Warshall, SK Moghaddam, T Nakagaki, Tiago P. Nascimento, Usman Ahmed Syed, V.S. Kalogeiton, Vasileios G. Ntinas, Vasilis Evangelidis, Vassilios A. Mardiris, Vicky S. Kalogeiton, X Zhang, XGM Wang, XJ Wu, Y Wang   +55 more
core   +1 more source

Why social scientists should engage with natural scientists [PDF]

, 2013
It has become part of the mantra of contemporary science policy that the resolution of besetting problems calls for the active engagement of a wide range of sciences.
Lowe, Philip, Phillipson, Jeremy, Wilkinson, Katy   +2 more
core   +1 more source

Is sustainability science becoming more interdisciplinary over time?

Acta Geographica Slovenica, 2012
The theoretical foundations of sustainability science about the interconnectedness of natural, socio-cultural and economic systems imply that the emerging research field transcends traditional boundaries of academic disciplines.
Maruša Nučič
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The essence and structure of the scientific outlook of future teachers of natural and mathematical specialties

Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського
The article highlights the author’s position regarding the algorithms for structuring the scientific outlook, as a category characterized by multidimensionality and a complex multifunctional composition.
Zelinha Yulia, Halitsan Olha
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Autoethnography and Subjective Experience in Marketing and Consumer Research (Autoetnografia e experiência subjetiva em marketing e pesquisa do consumidor) [PDF]

, 2016
Marketing and consumer research is often associated with the methods of natural science applied to experimental and survey data, but there are also strong traditions of interpretive and qualitative work that draw on disciplines such as qualitative ...
Hackley, Christopher, Hackley, Rungpaka Amy   +1 more
core   +1 more source

Challenges for Interdisciplinary Use in Forest Management Prompts of Coalition of Forest Management, Economic and Institutional Sciences: 2005, 361 pages

Jurnal Manajemen Hutan Tropika, 2014
In general, the science of forest management provides guidance on how forest managers set the forest, so that it is ready to be sustainably managed and used. The forest setting is based on the natural properties of forest - bio- physical characteristics,
Hariadi Kartodihardjo
doaj   +3 more sources