Results 71 to 80 of about 77,443 (304)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Is sustainability science becoming more interdisciplinary over time?
Acta Geographica Slovenica, 2012 The theoretical foundations of sustainability science about the interconnectedness of natural, socio-cultural and economic systems imply that the emerging research field transcends traditional boundaries of academic disciplines.
Maruša Nučič
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. УшинськогоThe article highlights the author’s position regarding the algorithms for structuring the scientific outlook, as a category characterized by multidimensionality and a complex multifunctional composition.
Zelinha Yulia, Halitsan Olha
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Data Science: a Natural Ecosystem
International audienceThis manuscript provides a systemic and data-centric view of what we term essential data science, as a natural ecosystem with challenges and missions stemming from the fusion of data universe with its multiple combinations of the 5D
Porcu, Emilio +4 more
core +1 more source
Explanation in Biology: Reduction, Pluralism, and Explanatory Aims [PDF]
, 2011 This essay analyzes and develops recent views about explanation in biology. Philosophers of biology have parted with the received deductive-nomological model of scientific explanation primarily by attempting to capture actual biological theorizing and ...
Brigandt, Ingo, Ingo Brigandt
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Jurnal Manajemen Hutan Tropika, 2014 In general, the science of forest management provides guidance on how forest managers set the forest, so that it is ready to be sustainably managed and used. The forest setting is based on the natural properties of forest - bio- physical characteristics,
Hariadi Kartodihardjo
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R.S. Belkin and the Establishment of Forensic Biology and Forensic Ecology
Теория и практика судебной экспертизы, 2017 Professor R.S. Belkin's role in the development of criminology and forensic science is widely recognized. The theory he advanced to connect criminalistics and the natural sciences was of great importance for the establishment of new forensic disciplines.
E. I. Maiorova
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