Results 101 to 110 of about 2,055,109 (284)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice

iScience
Summary: Dengue virus (DENV) is a mosquito-transmitted flavivirus; there are four serotypes (DENV1-4) that co-circulate globally. Primary infection causes self-limiting febrile illness, but secondary infection by a heterologous serotype can predispose to
Margarette C. Mariano, Helen S. Jung, Olivia Vergnolle, Keith Haskell, Lamount R. Evanson, Gregory Quevedo, Julia C. Frei, Karen Tong, Larissa B. Thackray, Michael S. Diamond, Jonathan R. Lai   +10 more
doaj   +1 more source

[Integration of natural sciences and basic medical subjects in the integrated dentistry program (iMED DENT) at the University of Hamburg]. [PDF]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2023
Bender R, Bruhn N, Eisenbarth S, Lemke R, Pantke CF, Hampe W, Schwoerer AP.   +6 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Shaping electrospray plume with convergent sound beams

iScience
Summary: Electrospray ionization (ESI) is one of the mainstream ionization techniques for mass spectrometry (MS) nowadays. Here, we present a new variant of ESI-MS setup, in which an electrospray emitter points to the mass spectrometer’s orifice while ...
Yu-Hao Chen, Min-Min Hung, Pawel L. Urban   +2 more
doaj   +1 more source

Exercise Physiology From 1980 to 2020: Application of the Natural Sciences. [PDF]

Kinesiol Rev (Champaign), 2021
Kent JA, Hayes KL.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Time-domain adjoint optimization for metalens design toward enhanced broadband efficiency and uniformity

iScience
Summary: We propose a time-domain adjoint optimization method for achromatic metalens design, achieving high efficiency and near-uniform spectral response.
Mingyu Park, Haejun Chung, Kyung-Young Jung   +2 more
doaj   +1 more source

Toward More Inclusive Metrics and Open Science to Measure Research Assessment in Earth and Natural Sciences. [PDF]

Front Res Metr Anal, 2022
Pourret O, Irawan DE, Shaghaei N, van Rijsingen EM, Besançon L.   +4 more
europepmc   +1 more source

The nature of science [PDF]

Nature, 1989
openaire   +2 more sources