Results 101 to 110 of about 24,744,506 (350)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice

iScience
Summary: Dengue virus (DENV) is a mosquito-transmitted flavivirus; there are four serotypes (DENV1-4) that co-circulate globally. Primary infection causes self-limiting febrile illness, but secondary infection by a heterologous serotype can predispose to
Margarette C. Mariano, Helen S. Jung, Olivia Vergnolle, Keith Haskell, Lamount R. Evanson, Gregory Quevedo, Julia C. Frei, Karen Tong, Larissa B. Thackray, Michael S. Diamond, Jonathan R. Lai   +10 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Shaping electrospray plume with convergent sound beams

iScience
Summary: Electrospray ionization (ESI) is one of the mainstream ionization techniques for mass spectrometry (MS) nowadays. Here, we present a new variant of ESI-MS setup, in which an electrospray emitter points to the mass spectrometer’s orifice while ...
Yu-Hao Chen, Min-Min Hung, Pawel L. Urban   +2 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Time-domain adjoint optimization for metalens design toward enhanced broadband efficiency and uniformity

iScience
Summary: We propose a time-domain adjoint optimization method for achromatic metalens design, achieving high efficiency and near-uniform spectral response.
Mingyu Park, Haejun Chung, Kyung-Young Jung   +2 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Natural Sciences at Parkland College [PDF]

, 2018
The Parkland College Natural Sciences Department Newsletter for Spring 2018 -- this issue features a review of ZipGrade, a summary of efforts to provide Green Infrastructure Certification at Parkland, a report on the Illinois Science Olympiad (Parkland ...
Garrett, Lori, Wendt, Lori, Leuszler, Heidi, Carlson, Britt, Parkland College Natural Sciences, Leake, David, Siechen, Scott, Wilson, David, Nicely, Amy, Blazier, Rich, Beatty, Christina   +10 more
core  

Regulation of addiction by the insular cortex: The interplay between interoception and cognitive function

iScience
Summary: The insular cortex (IC) functions as a pivotal core for interoception. Functional magnetic resonance imaging reveals how the IC integrates internal and external stimuli by observing its neural activation patterns.
Dan Tao, Shihao Huang, Zhihao Song, Jing Wen, Ewa Galaj, Yixiao Luo   +5 more
doaj   +1 more source

A case for beta regression in the natural sciences

Ecosphere, 2022
Emilie A. Geissinger, C. Khoo, I. Richmond, Sally J. M. Faulkner, David C. Schneider   +4 more
semanticscholar   +1 more source