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The natural selection of conservative science [PDF]

Studies in History and Philosophy of Science Part A, 2019
Social epistemologists have argued that high risk, high reward science has an important role to play in scientific communities. Recently, though, it has also been argued that various scientific fields seem to be trending towards conservatism -- the increasing production of what Kuhn (1970) would have called `normal science'.
openaire   +5 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Learning, economies of scale, and knowledge gap effects on power generation technology cost improvements

iScience
Summary: Cost reductions are essential for accelerating clean technology deployment. Because multiple factors influence costs, traditional one-factor learning models, solely relying on cumulative installed capacity as an explanatory variable, may ...
Yoga W. Pratama, Matthew J. Gidden, Jenna Greene, Andrew Zaiser, Gregory Nemet, Keywan Riahi   +5 more
doaj   +1 more source

Inferring the shape of data: a probabilistic framework for analysing experiments in the natural sciences. [PDF]

Proc Math Phys Eng Sci, 2022
Ray KK, Verma AR, Gonzalez RL, Kinz-Thompson CD.   +3 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Optical characteristics of laser medical instrument with side-firing fiber under complete bevel angle range

iScience
Summary: The side-firing instrument is studied under the complete bevel angle range. The fiber core and cladding are 0.6 mm and 0.66 mm, respectively, the fiber core refractive index is 1.457, and the fiber cladding refractive index is from 1.409 to 1 ...
Diqing Ying
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The first specific probe for pyrrolidine with multifunction by the interaction mechanism of atomic economic reaction

iScience
Summary: Pyrrolidine (PyD) has an important impact on the environment and human health. However, there is currently no method for trace detection of PyD. Here, we successfully designed diaminomethylene-4H-pyran (1) as the first specific fluorescent probe
Xi-Ying Cao, Yan Huang, Si-Hong Chen, Shi-Wei Yu, Zu-Jia Chen, Zhong-Hao Li, Yu Zeng, Nan Chen, Liang Cao, Zhao-Yang Wang   +9 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Preservice Primary Teachers' Perceptions of STEM-Based Teaching in Natural Sciences and Technology Classrooms. [PDF]

Can J Sci Math and Technol Educ, 2022
Mafugu T, Tsakeni M, Jita LC.
europepmc   +1 more source