Results 91 to 100 of about 1,689,166 (267)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Time-domain adjoint optimization for metalens design toward enhanced broadband efficiency and uniformity

iScience
Summary: We propose a time-domain adjoint optimization method for achromatic metalens design, achieving high efficiency and near-uniform spectral response.
Mingyu Park, Haejun Chung, Kyung-Young Jung   +2 more
doaj   +1 more source

Toward More Inclusive Metrics and Open Science to Measure Research Assessment in Earth and Natural Sciences. [PDF]

Front Res Metr Anal, 2022
Pourret O, Irawan DE, Shaghaei N, van Rijsingen EM, Besançon L.   +4 more
europepmc   +1 more source

The nature of science [PDF]

Nature, 1989
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Regulation of addiction by the insular cortex: The interplay between interoception and cognitive function

iScience
Summary: The insular cortex (IC) functions as a pivotal core for interoception. Functional magnetic resonance imaging reveals how the IC integrates internal and external stimuli by observing its neural activation patterns.
Dan Tao, Shihao Huang, Zhihao Song, Jing Wen, Ewa Galaj, Yixiao Luo   +5 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Cannabinoid overrides triggers of GABAergic plasticity in vestibular circuits and distorts the development of navigation

iScience
Summary: Early life exposure to cannabis can result in long-lasting deficits in spatial navigation. We ask if the development of this behavior is subject to early life activity of type I cannabinoid receptor (CB1R) in the vestibular nucleus.
Wei Shi, Kenneth Lap-Kei Wu, Mengliu Yang, Francisco Paulo De Nogueira Botelho, Oscar Wing-Ho Chua, Hui-Jing Hu, Ka-Pak Ng, Ulysses Tsz-Fung Lam, Kin-Wai Tam, Chun-Wai Ma, Daisy Kwok-Yan Shum, Ying-Shing Chan   +11 more
doaj   +1 more source

A deeper look into natural sciences with physics-based and data-driven measures. [PDF]

iScience, 2021
Rodrigues DR, Everschor-Sitte K, Gerber S, Horenko I.   +3 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source