Results 111 to 120 of about 12,333,506 (361)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Scientific research in the natural sciences in South Africa: A scientometric study

open access: yes, 2013
As a leading producer of scientific publications on the African continent, South Africa has made remarkable progress. However, attempts are yet to be made to comprehend the empirical reality of scientific production in South Africa. One way to do this is
R. Sooryamoorthy
semanticscholar   +1 more source

Clinical applications of nanoprobes of high-resolution in vivo imaging

open access: yesiScience
Summary: Currently, the primary imaging methods used in clinical diagnosis are X-ray, computed tomography (CT), ultrasound, magnetic resonance imaging (MRI), PET-CT, etc.
Shuning Kong   +4 more
doaj  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Ga@MXene-based flexible wearable biosensor for glucose monitoring in sweat

open access: yesiScience
Summary: Most wearable biosensors struggle to balance flexibility and conductivity in their sensing interfaces. In this study, we propose a wearable sensor featuring a highly stretchable, three-dimensional conductive network structure based on liquid ...
Wensi Zhang   +4 more
doaj  

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

“PyTDL”: A versatile temporal difference learning algorithm to simulate behavior process of decision making and cognitive learning

open access: yesiScience
Summary: Humans and animals excel at learning complex tasks through reward-based feedback, dynamically adjusting value expectations and choices based on past experiences to optimize outcomes. However, understanding the hidden cognitive components driving
Qiyun Wu   +5 more
doaj  

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