Results 111 to 120 of about 12,501,152 (388)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Basin dependencies of tropical cyclone genesis environment and possible future changes revealed by machine learning methods

iScience
Summary: Tropical cyclone (TC) genesis mechanisms remain debated, complicating predictions of climate change impacts. This study uses principal-component analysis (PCA), confidence ellipses, and correlation circles to analyze TC genesis environments ...
QiFeng Qian, YeFeng Chen, XiaoJing Jia, Hao Ma, Wei Dong   +4 more
doaj  

Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context

iScience, 2023
Summary: Accumulation and selection of nucleotides is one of the most challenging problems surrounding the origin of the first RNA molecules on our planet.
Judit E. Šponer, Jiří Šponer, Jakub Výravský, Roman Matyášek, Aleš Kovařík, Wojciech Dudziak, Katarzyna Ślepokura   +6 more
doaj  

Natural sciences and chess: A romantic relationship missing from higher education curricula. [PDF]

Heliyon, 2023
Uskoković V.
europepmc   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

The role of platelet-rich plasma in biomedicine: A comprehensive overview

iScience
Summary: Biomedicine has seen significant advancements in the 21st century, with platelet-rich plasma (PRP) playing a crucial role in clinical practice.
Zhixin Zhang, Peng Liu, Xinmiao Xue, Zhiyu Zhang, Li Wang, Yvke Jiang, Chi Zhang, Hanwen Zhou, Shuhan Lv, Weidong Shen, Shiming Yang, Fangyuan Wang   +11 more
doaj  

Exceptionally well-preserved crocodilian coprolites from the Late Eocene of Northern Vietnam: Ichnology and paleoecological significance

iScience, 2023
Summary: This study examines 55 coprolites from the Na Duong Basin to reconstruct the paleoenvironment. Coproecology sheds light on understanding the complex prey-predator relationships, trophic dynamics, and ecosystem evolution. Through quantitative and
Kazım Halaçlar, Paul Rummy, Jia Liu, Adrian P. Hunt, Truong Van Do, Nguyen Trung Minh, Tao Deng   +6 more
doaj  

Tablet-Based Praxis Developed for Children in Primary Education Studying Natural Sciences and Mathematics. [PDF]

Children (Basel), 2023
Ricoy MC, Sánchez-Martínez C.
europepmc   +1 more source

Putting Natural Time into Science [PDF]

arXiv, 2019
This contribution argues that the notion of time used in the scientific modeling of reality deprives time of its real nature. Difficulties from logic paradoxes to mathematical incompleteness and numerical uncertainty ensue. How can the emergence of novelty in the Universe be explained?
arxiv  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source