Results 51 to 60 of about 80,453 (305)

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Fusion of children’s speech and 2D gestures when conversing with 3D characters [PDF]

open access: yes, 2006
Most existing multi-modal prototypes enabling users to combine 2D gestures and speech input are task-oriented. They help adult users solve particular information tasks often in 2D standard Graphical User Interfaces. This paper describes the NICE Andersen
BERNSEN, Niels Ole   +7 more
core   +1 more source

Smart Web-Based Platform to Support Physical Rehabilitation

open access: yesSensors, 2018
The enhancement of ubiquitous and pervasive computing brings new perspectives in medical rehabilitation. In that sense, the present study proposes a smart, web-based platform to promote the reeducation of patients after hip replacement surgery.
Yves Rybarczyk   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Kansei Engineering in Designing Web-Based e-Commerce UMKM Product

open access: yesJOIN: Jurnal Online Informatika, 2021
Human-Computer Interaction (HCI) is a part of the development of a system in addition to the usability factor. Several methods were developed in HCI to produce a User Interface design that persuasively attracts the user’s interest. One of these methods
Indra Griha Tofik Isa, Indri Ariyanti
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Personalized Experiences for End-User Programming on the Web [PDF]

open access: yes, 2009
In this position paper we explore current work in AtomsMasher, an end-user reactive programming environment for the Web, highlight ongoing work in user interface design, privacy, and sharing, and look towards a future of extending end-user programming ...
Van Kleek, Max   +3 more
core  

Surface EMG-based Surgical Instrument Classification for Dynamic Activity Recognition in Surgical Workflows

open access: yesCurrent Directions in Biomedical Engineering, 2019
We introduce a wearable-based recognition system for the classification of natural hand gestures during dynamic activities with surgical instruments.
Bieck Richard   +2 more
doaj   +1 more source

Designing a Natural User Interface to Support Information Sharing among Co-Located Mobile Devices

open access: yesSouth African Computer Journal, 2018
Users of mobile devices share their information through various methods, which are supported by mobile devices. However, the information sharing process of these methods are typically redundant and sometimes tedious.
Timothy Lee Son   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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