Results 101 to 110 of about 3,530,202 (329)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Coupling Modeling Approaches for the Assessment of Runoff Quality in an Urbanizing Catchment
HydrologyThe impacts of land use on stormwater runoff quality and Best Management Practices to mitigate these impacts have been investigated since the 1970s, yet challenges remain in providing a modeling approach that concomitantly considers contributions from ...
Lihoun Teang +3 more
doaj +1 more source
Journal of Environmental ManagementNature-based solutions (NbS) represent a critical umbrella concept encompassing measures that employ nature's properties to systemically address societal challenges, potentially providing benefits for biodiversity, climate and people. NbS are accordingly emerging on an ever-expanding number of policy agendas, such as the Kunming-Montreal Global ...
Martin, Juliette G.C. +6 more
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
HydrologyRapid suburbanization can alter catchment flow regime and increase stormwater runoff, posing threats to sensitive ecosystems. Applications of Nature-based Solutions (NbS) have increasingly been adopted as part of integrated water management efforts to ...
Lihoun Teang +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Building the Case for Nature-Based Solutions: Enablers and Barriers in Data-Driven Solutions for Climate Adaptive Developments [PDF]
, 2020 Jeremy Anterola +3 more
openalex +1 more source
Centralized versus market-based approaches to mobile task allocation problem: State-of-the-art [PDF]
, 2009 Centralized approach has been adopted for finding solutions to resource allocation problems (RAPs) in many real-life applications. On the other hand, market-based approach has been proposed as an alternative to solve the problem due to recent advancement
Al-Yafi, K, Lee, H
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source