Results 111 to 120 of about 1,350,046 (300)

Coupling Modeling Approaches for the Assessment of Runoff Quality in an Urbanizing Catchment

Hydrology
The impacts of land use on stormwater runoff quality and Best Management Practices to mitigate these impacts have been investigated since the 1970s, yet challenges remain in providing a modeling approach that concomitantly considers contributions from ...
Lihoun Teang, Kim N. Irvine, Lloyd H. C. Chua, Muhammad Usman   +3 more
doaj   +1 more source

Unlocking Policy for Nature Based Solutions: Stage 2 - Summary Report for Stakeholder Feedback

iCASP was awarded funding from the University of Leeds - Research England Policy Fund to develop an evidence base to unlock policy to support implementation of Nature Based Solutions (NBS) in England. The project seeks to identify policy barriers in
Barlow-Duncan, F., Ramsden, S., Holden, J., Klaar, M.   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dynamics of Runoff Quantity in an Urbanizing Catchment: Implications for Runoff Management Using Nature-Based Retention Wetland

Hydrology
Rapid suburbanization can alter catchment flow regime and increase stormwater runoff, posing threats to sensitive ecosystems. Applications of Nature-based Solutions (NbS) have increasingly been adopted as part of integrated water management efforts to ...
Lihoun Teang, Kim N. Irvine, Lloyd H. C. Chua, Muhammad Usman   +3 more
doaj   +1 more source

Intelligent nature-based solutions in the 1st smart sustainable Brazilian City: Insights and lessons learned

As urbanization intensifies worldwide, the need for sustainable urban development becomes increasingly critical. This study introduces a novel approach, the Intelligent Nature-based Solutions (INbS), which encompasses the integration of nature-based ...
Líliam César de Castro Medeiros, Moruzzi, Rodrigo [UNESP], Negri, Rogério Galante [UNESP], Medeiros, Líliam César de Castro [UNESP], Rodrigo Moruzzi, Adriano Bressane, Bressane, Adriano [UNESP], Saraiva, Antônio Carlos Varela [UNESP], Anna Isabel Silva Loureiro, Jorge Kennety Silva Formiga, Rogério Galante Negri, Antônio Carlos Varela Saraiva, Loureiro, Anna Isabel Silva [UNESP], Formiga, Jorge Kennety Silva [UNESP]   +13 more
core   +1 more source

Nature-based solutions in Europe. The Road map.

, 2023
Nature-based solutions (NBS) are increasingly applied to guide the design of resilient landscapes and cities to enable them to reach economic development goals with beneficial outcomes for sustainability, resilience, ecosystem services, coupled human and
Raffaele Lafortezza
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source