Results 141 to 150 of about 3,489,691 (328)

River Re-naturalization - a Nature-based Solution for Climate Change in Urban Areas

, 2021
Katarzyna Mazur
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Investigating the influence of residents' attitudes, perceptions of risk, and subjective norms on their willingness to engage in flood prevention efforts in Freetown, Sierra Leone

Nature-Based Solutions
This study investigates the intricate relationships between flood disaster risk perception (RP), attitudes(ATT), subjective norms(SN), and participation in flood prevention activities(IPF), emphasizing the mediating roles of self-efficacy(SE) and bonding
Ibrahim Abdulai Sawaneh, Luo Fan, Brima Sesay   +2 more
doaj   +1 more source

Innovations in Nature-Based Solutions for Urban Flood Management in the Global South [PDF]

Sabastine Obum Aniebonam
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Charland resilience: Agroforestry innovations as nature-based solutions for climate-vulnerable communities in Bangladesh

Nature-Based Solutions
The study emphasizes the need for sustainable solutions in highly vulnerable regions such as Bangladesh's charlands, where climate hazards are rising.
M.M. Ali, M.S. Bari, M.A. Hanif, M.S. Rahman, B. Ahmed, M.S. Rahman   +5 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Optimizing green infrastructure strategies for microclimate regulation and air quality improvement in urban environments: A case study

Nature-Based Solutions
With an increasing global urban population andassociated health concerns, understanding the effects of urban microclimate and air quality is crucial.
Soniya Kaveh, Amin Habibi, Mohammad Nikkar, Ardalan Aflaki   +3 more
doaj   +1 more source

Book Review Dhyani, S., Gupta, A.K. and Karki, M. (Editors). 2020. Nature-based Solutions for Resilient Ecosystems and Societies. Springer Nature, Singapore. X + 455 pages. ISBN ISBN 978-981-15-4712-6 (eBook). Euro 117.69.

, 2022
Kottapalli Sreenivasa Rao
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source