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Cellular targets of natural products
Natural Product Reports, 2007Natural products have evolved, at least in part, to bind to biological macromolecules, particularly proteins. As a result, natural products are able to interact with many specific targets within the cell. Indeed for many years this has been central in the drug development process. Today, however, natural products are finding increasing use as probes to
Dixon, Neil +3 more
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Synthesis of ellagitannin natural products
Natural Product Reports, 2011Covering: up to the beginning of 2011 A detailed overview of chemical synthesis approaches to ellagitannins is provided. This unique family of natural products, which belong to the hydrolysable tannin class of plant polyphenols, today features nearly 1000 members that have been fully characterised, from monomeric to oligomeric and complex ...
Laurent, Pouységu +4 more
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Natural Product Inhibitors of Acetylcholinesterase
Current Organic Chemistry, 2006Various natural products, such as physostigmine, have long been recognized as inhibitors of the enzyme acetylcholinesterase. Since the recent approval of galanthamine for the treatment of Alzheimer's disease by the blockage of acetylcholine degradation, attempts to find other inhibitors of the enzyme have multiplied, leading to promising candidates ...
Hostettmann, Kurt +3 more
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Structural variety of natural products
Journal of Chemical Education, 1962Classes of natural products examined includes alkynes; quinones; benzpyrones; small and large rings; sulfur, nitrogen, and halogen-containing compounds; and new amino acids.
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The Polypharmacology of Natural Products
Future Medicinal Chemistry, 2018The once-popular approach of using natural products as a prime source for medicinal chemistry and drug discovery has waned considerably in the past two decades due to the advent of high-throughput screening of small molecule mega libraries. However, the growing appreciation of network pharmacology as the next drug-discovery paradigm suggests that ...
Tu T, Ho +2 more
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Supramolecular complexations of natural products
Chemical Society Reviews, 2013Complexations of natural products with synthetic receptors as well as the use of natural products as host compounds are reviewed, with an emphasis on possible practical uses or on biomedical significance. Applications such as separation, sensing, enzyme monitoring, and protection of natural drugs are first outlined.
Hans-Jörg, Schneider +2 more
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Capillary electrophoresis of natural products
ELECTROPHORESIS, 1997AbstractCapillary electrophoresis (CE) and micellar electrokinetic chromatography were used for the separation of widely different compounds from natural materials including antibiotics, humic substances, flavonoids, isoflavonoids, illicit drugs, coumarins, alkaloids, steroids, Chinese herbal preparations, nicotine, caffeine, amphetamines, toxins such ...
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Synthesis of Diquinane Natural Products
1987Hirsutene (1124) is the simplest member of a group of fungal metabolites possessing the linearly fused cis,anti,cis-tricyclo[6.3.0.02,6]undecane carbon skeleton [503]. As a result of the antibiotic and antitumor properties shown by some of these triquinanes, synthetic chemists have strived to devise new annulation procedures for their construction ...
Leo A. Paquette, Annette M. Doherty
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Cheminformatics Explorations of Natural Products
2019The chemistry of natural products is fascinating and has continuously attracted the attention of the scientific community for many reasons including, but not limited to, biosynthesis pathways, chemical diversity, the source of bioactive compounds and their marked impact on drug discovery.
Fernando D, Prieto-Martínez +2 more
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