Results 31 to 40 of about 327,545 (257)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Palliation of nausea and vomiting

, 2015
Nausea and vomiting (NV) are unpleasant symptoms reported as highly distressing by sufferers and have a significant impact on activities of daily living. The prevalence of nausea is 6-68% in people with advanced cancer, 17-48% in heart disease, 30-43% in
Janet R. Hardy, Yates, Patsy, Paul Glare, Patsy Yates, Hardy, Janet R., Glare, Paul, Mannix, Kathryn A., Kathryn A. Mannix   +7 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Unusual cause of nausea and vomiting [PDF]

Journal of Clinical and Scientific Research, 2016
Adrenal insufficiency can manifest with various symptoms ranging from haemodynamic compromise to non-specific symptoms like myalgia, anorexia, and loss of weight. Aetiology can be primary adrenal disorder or secondary to suppression of HPA axis.
Nandakrishna B, Muralidhar V, Vidyasagar S   +2 more
doaj   +1 more source

New therapies to treat nausea and vomiting: the clinical need, progress towards novelty and research challenges. [PDF]

INTRODUCTION: Despite the availability of drugs which prevent vomiting, treatment gaps in controlling nausea and vomiting remain. New approaches are needed.
Andrews, PLR, Sanger, GJ, Golding, JF, Andrews, P.L., Golding, J.F., Sanger, G.J.   +5 more
core   +1 more source

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Prophylactic Effect of Dexamethasone on Postoperative Nausea and Vomiting in Patients Undergoing Tympanomastoid Surgery [PDF]

Journal of Kerman University of Medical Sciences, 2003
Postoperative nausea and vomiting is an unpleasant, distressing, and exhausting experience for patient. This is more common and severe in tympanomastoid surgery. The role of dexamethasone prevention of this complication is unclear and during recent years
J Saied, S.M.R Ahmadi-Moosavi, H Eslami
doaj  

Effect of Inhaled Peppermint Aromatherapy on Chemotherapy-Induced Acute Nausea and Vomiting among Women with Breast Cancer in Gresik Regency

Indonesian Journal of Cancer, 2023
Background: Chemotherapy-induced acute nausea and vomiting are commonly experienced by breast cancer patients. Therefore, this study aimed to determine the effect of inhaled peppermint aromatherapy on chemotherapy-induced acute nausea and vomiting among ...
Istiroha Istiroha, Roihatul Zahroh, Qonitatin Wafiyah, Yuanita Syaiful   +3 more
doaj   +1 more source

Ofatumumab Therapy and Long‐Term Seizure Outcomes of Patients With Relapsing Anti‐NMDA Receptor Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There is a lack of studies on seizure outcomes associated with ofatumumab therapy in patients for relapsing anti‐N‐methyl‐D‐aspartate (NMDA) receptor encephalitis. We aimed to evaluate long‐term seizure outcomes of ofatumumab therapy for relapsing anti‐NMDA receptor encephalitis.
Jian Wang, Mengjiao Li, Ping Kong
wiley   +1 more source

EFFECT OF COUNSELLING ON FREQUENCY AND SEVERITY OF NAUSEA AND VOMITING IN PREGNANCY (NVP)

Indonesian Midwifery and Health Sciences Journal, 2021
Background: Nausea and vomiting are commonly during early pregnancy. Nausea and vomiting significantly decrease in quality of life. Objective:This study aimed to explain the effect of counseling on the frequency and level of nausea and vomiting in ...
Luh Sukeningsih, Baksono Winardi, Tiyas Kusumaningrum   +2 more
doaj   +1 more source