Results 11 to 20 of about 18,388 (225)

Left-shifted Nav channels in injured bilayer: primary targets for neuroprotective Nav antagonists? [PDF]

Frontiers in Pharmacology, 2012
In sodium channel (Nav)-rich axon initial segments and nodes of Ranvier, mechanical, ischemic and inflammatory injuries render these voltage-gated channels dangerously leaky.
Catherine E Morris, Pierre Alexandre Boucher, Bela eJoos   +2 more
doaj   +4 more sources

Antigen-Detected NMR for Minimal Epitope Engineering and Structure-Guided Selection of a Na_V1.7-Selective Nanobody. [PDF]

Adv Sci (Weinh)
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Liu J, Chen W, Cristofori-Armstrong B, Crawford T, Chen KE, Xie P, Chan RWB, Zhu Y, Golder M, Pereira Schmidt A, Naughton JD, Condon ND, Andersson Å, Dehkhoda F, McMahon KL, Klasfauseweh T, Thapa A, Tran H, Tran P, Jami S, Ragnarsson L, Furness SGB, Deuis JR, Collins BM, Tham WH, Prasadam I, Vetter I, Mobli M.   +27 more
europepmc   +2 more sources

Arbeidsmiljøundersøkelse i NAV. [PDF]

AFI-Notater, 2009
Tilsynsrapporten presenterer resultatene fra arbeidsmiljøundersøkelsen i NAV gjennomført høsten 2009. Spørreskjema ble sendt ut til 15 000 ansatte fordelt på 25 NAV-enheter. Rapporten viser at arbeidsmiljøet i NAV ikke er fullt ut forsvarlig for alle medarbeidere.
openaire   +2 more sources

A safe reinforcement learning approach for autonomous navigation of mobile robots in dynamic environments

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract When deploying mobile robots in real‐world scenarios, such as airports, train stations, hospitals, and schools, collisions with pedestrians are intolerable and catastrophic. Motion safety becomes one of the most fundamental requirements for mobile robots.
Zhiqian Zhou, Junkai Ren, Zhiwen Zeng, Junhao Xiao, Xinglong Zhang, Xian Guo, Zongtan Zhou, Huimin Lu   +7 more
wiley   +1 more source

Novel Na_V1.6-Mitochondrial Complexes in Retinal Astrocyte Pockets Sequester GABA. [PDF]

Glia
NaV1.6 localizes in retinal astrocytes' high density pockets on the bilayer facing the ganglion cell layer. NaV colocalizes with large, anaplerotic mitochondria. These microdomains accumulate high levels of GABA. ABSTRACT Voltage‐gated sodium channels are best known for their capacity to generate and propagate electrical currents in neurons and muscle.
Holden JM, Calkins DJ.
europepmc   +2 more sources

A population of in silico models identifies the interplay between Nav 1.8 conductance and potassium currents as key in regulating human dorsal root ganglion neuron excitability [version 1; peer review: 1 approved, 3 approved with reservations]

F1000Research, 2022
Background: The Nav 1.8 sodium channel has a key role in generating repetitive action potentials in nociceptive human dorsal root ganglion neurons. Nav 1.8 is differentiated from other voltage-gated sodium channels by its unusually slow inactivation ...
Blanca Rodriguez, Oliver J. Britton
doaj   +1 more source

Multiple spørsmål i digital veiledning: ‘Skriftlige samtaler’ mellom brukere og veiledere på NAVs digitale plattform

Norsk Lingvistisk Tidsskrift, 2023
I NAV foregår interaksjonen mellom brukerne og veilederne i stor grad som ‘skriftlige samtaler’ via meldinger på en digital plattform. Med utgangspunkt i et samtaleanalytisk og sekvensielt perspektiv på digital interaksjon, undersøker vi hvordan ...
Kristin Halvorsen, Liv Bente Strømhaug
doaj  

Advancements in Solar-Powered UAV Design Leveraging Machine Learning: A Comprehensive Review [PDF]

E3S Web of Conferences
Unmanned Aerial Vehicles (UAVs), commonly known as drones, have seen significant innovations in recent years. Among these innovations, the integration of solar power and machine learning has opened up new horizons for enhancing UAV capabilities.
R Hariharan, Saxena Archana, Dhote Vijay, S Srisathirapathy, Almusawi Muntather, Raja Kumar Jambi Ratna   +5 more
doaj   +1 more source

La politica marittima di Bernardo Tanucci nell'epistolario con Carlo III Re di Spagna

Cuadernos de Ilustración y Romanticismo, 2019
Trusted advisor of Charles of Bourbon, after having held prestigious positions until 1758, when Charles left for Spain, Tanucci was chosen by the king as an authoritative member of the Council of Regency until 1767, when the king Ferdinand reached the ...
Maria Sirago
doaj   +1 more source

Fremmed i NAV [PDF]

Norsk Sosiologisk Tidsskrift, 2018
I denne artikkelen presenterer vi en institusjonell etnografi av NAVs oppfølging av arbeidsledige. Basert på en dokumentanalyse og dybdeintervjuer med arbeidsledig ungdom og NAV-ansatte, utforsker vi hvordan målingen av arbeidsevne er organisert i praksis, og hvilke konsekvenser denne organiseringen får for de arbeidslediges hverdag.
Emil Øversveen, Ulla Forseth
openaire   +4 more sources