Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. [PDF]
, 2019 ObjectiveMicroglia play a pivotal role in the initiation and progression of Alzheimer's disease (AD). We here tested the therapeutic hypothesis that the Ca2+-activated potassium channel KCa3.1 constitutes a potential target for treating AD by reducing ...
Bushong, Trevor +8 more
core +2 more sources
Advanced Science, Volume 12, Issue 42, November 13, 2025.The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang +28 more
wiley +1 more source
Contrasting Nav1.8 Activity in Scn10a −/− Ventricular Myocytes and the Intact Heart [PDF]
Journal of the American Heart Association, 2016 Background Genome‐wide association studies have implicated variants in SCN 10A , which encodes Nav1.8, as modulators of cardiac conduction. Follow‐up work has indicated the SCN 10A
Dina Myers Stroud +12 more
openaire +3 more sources
Nociception and pain: lessons from optogenetics [PDF]
, 2014 The process of pain perception begins in the periphery by activation of nociceptors. From here nociceptive signals are conveyed via the dorsal horn of the spinal cord to multiple brain regions, where pain is perceived.
Fiona B. Carr, Venetia Zachariou
core +2 more sources
Computational modeling to study the impact of changes in Nav1.8 sodium channel on neuropathic pain
Frontiers in Computational NeuroscienceObjectiveNav1.8 expression is restricted to sensory neurons; it was hypothesized that aberrant expression and function of this channel at the site of injury contributed to pathological pain.
Peter Kan +4 more
doaj +1 more source
Acta Physiologica, Volume 241, Issue 11, November 2025.ABSTRACT Aim To elucidate the molecular mechanism of cold sensing by visceral sensory endings, a side‐by‐side characterization of cold‐sensitive (CS) neurons in adult mouse trigeminal (TG) and vagal ganglia (VG) was performed. Methods A combination of physiological, pharmacological, molecular, and genetic tools was employed on trigeminal and vagal ...
Katharina Gers‐Barlag +4 more
wiley +1 more source
Functional Properties and Toxin Pharmacology of a Dorsal Root Ganglion Sodium Channel Viewed through its Voltage Sensors [PDF]
, 2013 The voltage-activated sodium (Nav) channel Nav1.9 is expressed in dorsal root ganglion (DRG) neurons where it is believed to play an important role in nociception.
Bean, Bruce Palmer +4 more
core +1 more source
The role of Nav1.9 channel in the development of neuropathic orofacial pain associated with trigeminal neuralgia [PDF]
, 2015 BACKGROUND: Trigeminal neuralgia is accompanied by severe mechanical, thermal and chemical hypersensitivity of the orofacial area innervated by neurons of trigeminal ganglion (TG).
Kopach, O +3 more
core +1 more source
Saltatory axonal conduction in the avian retina
The Journal of Physiology, Volume 603, Issue 21, Page 6533-6547, November 1, 2025.Abstract figure legend Intraretinal axonal spike conduction was studied across multiple avian and mammalian species using high‐resolution multielectrode arrays. On the electrode array, saltatory axonal spike conduction was readily apparent and distinguishable from non‐saltatory conduction.
Christoph T. Block +5 more
wiley +1 more source
Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves [PDF]
, 2008 Neuropathic pain may arise following peripheral nerve injury though the molecular mechanisms associated with this are unclear. We used proteomic profiling to examine changes in protein expression associated with the formation of hyper-excitable neuromas ...
Cendan, C.M. +6 more
core +3 more sources