Results 101 to 110 of about 8,067 (198)
Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances [PDF]
, 2018 Synthetic pyrethroid insecticides were introduced into widespread use for the control of insect pests and disease vectors more than three decades ago.
Soderlund, David
core
Quality in SportIntroduction: Pain is a complex clinical challenge, with opioids traditionally used despite the risks of dependency and overdose. The need for safer alternatives has led to growing interest in voltage-gated sodium channels, particularly NaV1.7, NaV1.8 ...
Aleksandra Kaniak +9 more
doaj +1 more source
The function of NaV1.8 clusters in lipid rafts
, 2014 NaV1.8 is a voltage gated sodium channel mainly expressed on the membrane of thin diameter c-fibre neurons involved in the transmission of pain signals. In these neurons NaV1.8 is essential for the propagation of action potentials. NaV1.8 is located in lipid rafts along the axons of sensory neurons and disruption of these lipid rafts leads to NaV1.8 ...
openaire +3 more sources
Frontiers in Pharmacology, 2019 Currently there is no effective treatment available for clinical patients suffering from neuropathic pain induced by chemotherapy paclitaxel. Puerarin is a major isoflavonoid extracted from the Chinese medical herb kudzu root, which has been used for ...
Xiao-Long Zhang +5 more
doaj +1 more source
Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1 [PDF]
, 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the ...
Brierley, Stuart M +15 more
core +1 more source
Molecular PainWe recently used Nav1.8-ChR2 mice in which Nav1.8-expressing afferents were optogenetically tagged to classify mechanosensitive afferents into Nav1.8-ChR2-positive and Nav1.8-ChR2-negative mechanoreceptors. We found that the former were mainly high threshold mechanoreceptors (HTMRs), while the latter were low threshold mechanoreceptors (LTMRs). In the
Akihiro Yamada +4 more
openaire +2 more sources
BMC Cardiovascular DisordersBackground The role of NaV1.8 impacts in atrial fibrillation susceptibility after myocardial infarction remains only partially understood. We studied the effect of blocking NaV1.8 in the cardiac ganglionated plexi (GP) on the atrial fibrillation ...
Baozhen Qi +7 more
doaj +1 more source
Neuronal voltage-gated sodium channel subtypes: Key roles in inflammatory and neuropathic pain [PDF]
, 2006 Voltage-gated sodium channels (VGSCs) play an important role in neuronal excitability. Regulation of VGSC activity is a complex phenomenon that occurs at multiple levels in the cell, including transcriptional regulation, post-translational modification ...
Adams, D. J., Ekberg, J.
core +1 more source
Nociceptive Sensory Neurons Drive Interleukin-23 Mediated Psoriasiform Skin Inflammation [PDF]
, 2015 The skin has a dual function as a barrier and a sensory interface between the body and the environment. To protect against invading pathogens, the skin harbors specialized immune cells, including dermal dendritic cells (DDCs) and interleukin (IL)-17 ...
Alvarez, David +7 more
core +1 more source
Calmodulin Regulation of Nav1.8 Channel [PDF]
Biophysical Journal, 2018 Liang Hong +5 more
openaire +1 more source