Results 111 to 120 of about 8,067 (198)

Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators [PDF]

, 2014
Resurgent sodium currents contribute to the regeneration of action potentials and enhanced neuronal excitability. Tetrodotoxin-sensitive (TTX-S) resurgent currents have been described in many different neuron populations, including cerebellar and dorsal ...
Cummins, Theodore R., Knopp, Kelly L., Krajewski, Jeffrey L., McDermott, Jeff S., Nisenbaum, Eric S., Piekarz, Andrew D., Priest, Birgit T., Tan, Zhi-Yong   +7 more
core   +3 more sources

ERK2 alone drives inflammatory pain but cooperates with ERK1 in sensory neuron survival [PDF]

, 2015
Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are highly homologous yet distinct components of signal transduction pathways known to regulate cell survival and function.
Alter, Benedict J, Davidson, Steve, Demaro, Joseph A, III, Gereau, Graydon B, Gereau, Robert W, IV, Golden, Judith P, Landreth, Gary E, Morgan, Clinton D, Norman, Megan E, O\u27Brien, Daniel E, Satomoto, Maiko, Vogt, Sherri K   +11 more
core   +2 more sources

Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms

Molecular Metabolism, 2018
Objectives: G protein-coupled receptors (GPCRs) act as transmembrane molecular sensors of neurotransmitters, hormones, nutrients, and metabolites. Because unmyelinated vagal afferents richly innervate the gastrointestinal mucosa, gut-derived molecules ...
Kristoffer L. Egerod, Natalia Petersen, Pascal N. Timshel, Jens C. Rekling, Yibing Wang, Qinghua Liu, Thue W. Schwartz, Laurent Gautron   +7 more
doaj   +1 more source

A small lipidated peptide targeting NaV1.8 channels attenuates osteoarthritic pain behavior and prevents bone erosion

Osteoarthritis and Cartilage Open
Objective: In clinical practice, intra-articular therapies are commonly used for the management of osteoarthritis (OA) pain. However, these current treatments for OA-related pain are recognized for compromising joint integrity over time.
Raider Rodriguez, Arin Bhattacharjee
doaj   +1 more source

Pharmacological Frontiers: The Rise of Selective NaV1.8 Inhibition for Pain Management

CNS Drugs
Pain is a multifaceted disorder encompassing sensory, emotional, and cognitive dimensions. It presents a ubiquitous challenge to human health and well-being, demanding effective and safe management strategies [1]. Various pharmacological interventions, including nonsteroidal anti-inflammatory drugs, antidepressants, anticonvulsants, and opioids, have ...
openaire   +3 more sources

Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective NaV1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain

Pain and Therapy
Introduction There is a high unmet need for safe and effective non-opioid medicines to treat moderate to severe pain without risk of addiction. Voltage-gated sodium channel 1.8 (NaV1.8) is a genetically and pharmacologically validated pain target that is
Jeremiah D. Osteen, Swapna Immani, Tim L. Tapley, Tim Indersmitten, Nicole W. Hurst, Tiffany Healey, Kathleen Aertgeerts, Paul A. Negulescu, Sandra M. Lechner   +8 more
doaj   +1 more source

Suzetrigine mechanism, efficacy, and clinical implications: A narrative review

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
Acute pain, especially in postoperative and trauma areas, continues to be a substantial clinical problem all around the world, and this has been made worse by the opioid crisis as well as the drawbacks of the current non-opioid analgesics.
Abduelmula R. Abduelkarem
doaj   +1 more source

Methylglyoxal; NaV1.8 (PN3; SCN10A) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice

Journal of Experimental Pharmacology, 2015
Ken-ichiro Tanaka,1,2, Shota Sekino,1 Megumi Ikegami,1 Hiroko Ikeda,1 Junzo Kamei11Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan; 2Department of Endocrinology and Metabolism,
Tanaka KI, Sekino S, Ikegami M, Ikeda H, Kamei J   +4 more
doaj  

Antinociceptive Effects of AGAP, a Recombinant Neurotoxic Polypeptide: Possible Involvement of the Tetrodotoxin-Resistant Sodium Channels in Small Dorsal Root Ganglia Neurons [PDF]

, 2016
Chun-Fu Wu, Chun-Li Li, Gui-Xia Li, Jian-Zhao Chen, Jing-Hai Zhang, Meng-qi Ban, Xi-Fang Liu, Yong Cui   +7 more
core   +1 more source