Results 181 to 190 of about 8,067 (198)

Differential modulation of Nav1.7 and Nav1.8 channels by antidepressant drugs

European Journal of Pharmacology, 2015
Antidepressant drugs of the SSRI family are used as a third-line treatment for neuropathic pain. In contrast MAOi antidepressants, that also increase extracellular serotonin bioavailability have little or no effects on this condition. In addition to their action of the serotonin transporter, some SSRI have been shown to inhibit voltage gated sodium ...
Olivier, Thériault, Hugo, Poulin, Jean-Martin, Beaulieu, Mohamed, Chahine   +3 more
openaire   +2 more sources

Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8

Molecular Brain Research, 2003
Voltage-gated sodium channels initiate and propagate action potentials in excitable cells. The tetrodotoxin-resistant Na(+) channel (Na(V)1.8/SNS) is expressed in damage-sensing neurons (nociceptors) and plays an important role in pain pathways. Expression of high levels of functional Na(V)1.8 in heterologous cells has proved problematic, even in the ...
Misbah, Malik-Hall, W-Y Louisa, Poon, Mark D, Baker, John N, Wood, Kenji, Okuse   +4 more
openaire   +2 more sources

[Expression of Nav1.8 in human dental pulp].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2013
To investigate the relationship between dental pain and Nav1.8 expression level by detecting the expression of voltage-gated sodium channel Nav1.8 in normal human dental pulps and painful pulp tissues.Immunohistochemistry, reverse transcription polymerase chain reaction (RT-PCR) and Western blotting were used to detect the expression of Nav1.8 in ...
Ran, Tao, Yong, Jiang
openaire   +1 more source

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

Pain, 2012
A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons, defined by specific neuropeptides, ion channels, or cytoskeletal proteins. Recent evidence has demonstrated a correlation between the expression of some of these molecular markers and transmission of signals related to distinct sensory modalities (eg, heat, cold,
Shannon D, Shields, Hye-Sook, Ahn, Yang, Yang, Chongyang, Han, Rebecca P, Seal, John N, Wood, Stephen G, Waxman, Sulayman D, Dib-Hajj   +7 more
openaire   +2 more sources

Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice

2020
Pharmacologic approaches for the treatment of atrial arrhythmias are limited due to side effects and low efficacy. Thus, the identification of new antiarrhythmic targets is of clinical interest. Recent genome studies suggested an involvement of SCN10A sodium channels (NaV1.8) in atrial electrophysiology. This study investigated the role and involvement
Pabel, Steffen, Ahmad, Shakil, Tirilomis, Petros, Stehle, Thea, Mustroph, Julian, Holzamer, Andreas, Hilker, Michael, Maier, Lars S., Sossalla, Samuel   +8 more
openaire   +2 more sources

Carbamazepine interacts with a slow inactivation state of NaV1.8-like sodium channels

Neuroscience Letters, 2006
Carbamazepine was tested on high-threshold TTX-resistant Na+ currents (TTX-R-currents), evoked from acutely isolated rat dorsal root ganglion (DRG) cells. Under control conditions, the TTX-R-currents recorded from different DRG cells varied greatly regarding use-dependent inactivation (TTX-R-current UDI), measured as the percent decrease in current ...
Carlos A, Cardenas, Carla G, Cardenas, Alberto J, de Armendi, Reese S, Scroggs   +3 more
openaire   +2 more sources

Discovery of a novel series of pyridone amides as NaV1.8 inhibitors

Bioorganic & Medicinal Chemistry Letters
The NaV1.8 channel, mainly found in the peripheral nervous system, is recognized as one of the key factors in chronic pain. The molecule VX-150 was initially promising in targeting this channel, but the phase II trials of VX-150 did not show expected pain relief results.
Yanfang, Wang, Shilong, Hu, Yuhao, Chen, Meiyuan, Chen, Di, Zhang, Wencheng, Liu, Chunxia, Chen, Yu, Gan, Menglan, Luo, Bowen, Ke   +9 more
openaire   +2 more sources

Vinpocetine Is a Potent Blocker of Rat NaV1.8 Tetrodotoxin-Resistant Sodium Channels

The Journal of Pharmacology and Experimental Therapeutics, 2003
Vinpocetine is a clinically used synthetic vincamine derivative with a diverse pharmacological profile that includes action at several ion channels, principally "generic" populations of sodium channels that give rise to tetrodotoxin-sensitive conductances.
Xiaoping, Zhou, Xiao-Wei, Dong, James, Crona, Maureen, Maguire, Tony, Priestley   +4 more
openaire   +2 more sources

Vertex’s NaV1.8 inhibitor passes phase II pain point

Nature Reviews Drug Discovery, 2022
openaire   +1 more source

siRNA-mediated knockdown of the Nav1.8 sodium channel

The Journal of Pain, 2005
S. Goregaoker, T. Machemer, M. Ramachandra, S. Wen, X. Jin, H. Engler Priestley   +5 more
openaire   +1 more source