Results 11 to 20 of about 8,067 (198)
A Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line [PDF]
Frontiers in Pharmacology, 2018 Among the nine voltage-gated sodium channel (NaV) subtypes, NaV1.8 is an attractive therapeutic target for pain. The heterologous expression of recombinant NaV1.8 currents is of particular importance for its electrophysiological and pharmacological ...
Xi Zhou +6 more
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Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9 [PDF]
Toxins, 2012 Human voltage-activated sodium (Nav) channels are adept at rapidly transmitting electrical signals across long distances in various excitable tissues. As such, they are amongst the most widely targeted ion channels by drugs and animal toxins. Of the nine
John Gilchrist, Frank Bosmans
doaj +4 more sources
Association of NaV1.8 with lipid rafts in DRG sensory neurons
, 2011 Voltage gated sodium channels (VGSCs) play a key role in the initiation and propagation of action potentials in neuronal cells. NaV1.8 is a Tetrodotoxin resistant VGSC expressed in nociceptors and underlies the majority of sodium currents during action
Pristera, Alessandro +1 more
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Toward Brain Na<sub>V</sub>1.8 Imaging with [<sup>11</sup>C]Suzetrigine. [PDF]
Pharmaceuticals (Basel)Background/Objective: Acute and chronic pain affect millions of individuals, yet there are currently no molecular imaging tools to directly assess pain-related mechanisms in the central nervous system (CNS). The voltage-gated sodium channel NaV1.8 plays a pivotal role in neuropathic pain by increasing the excitability of nociceptive neurons following ...
Tokala R +7 more
europepmc +2 more sources
Distribution of Voltage-Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment. [PDF]
J Comp NeurolVarious sodium channel isoforms and their scaffolding proteins are found in four different microdomains in vestibular calyx‐bearing afferents. These microdomains serve different purposes, analogous to the heminode, axon initial segment, and synaptic domains of other types of sensory afferents.
Lysakowski A +8 more
europepmc +2 more sources
Letter to the Editor on NaV1.8 [PDF]
Circulation Research, 2012 Letters to the Editor will be published, if suitable, as space permits. They should not exceed 1000 words (typed double-spaced) in length and may be subject to editing or abridgment.
Randy E, Numann, John K, Gibson
openaire +2 more sources
Suzetrigine, a Non-Opioid Small-Molecule Analgesic: Mechanism of Action, Clinical, and Translational Science. [PDF]
Clin Transl SciABSTRACT The discovery and approval of Suzetrigine (VX‐548, Journavx) marks a significant breakthrough in pain management. It is the first non‐opioid analgesic approved since celecoxib in 1998. Suzetrigine selectively blocks voltage‐gated sodium channel Nav1.8 and acts exclusively on peripheral nociceptors without crossing the blood–brain barrier ...
Rajasingham R, Qi Y.
europepmc +2 more sources
Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain
Frontiers in Cellular Neuroscience, 2022 While current research highlights the role of Nav1. 8 sensory neurons from the peripheral nervous system, the anatomical and physiological characterization of encephalic Nav1.8 neurons remains unknown. Here, we use a Cre/fluorescent reporter mouse driven
Helia Tenza-Ferrer +10 more
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iScience, 2023 Summary: Previous studies validate that inhibiting sodium channel 1.8 (Nav1.8) effectively relieves inflammatory and neuropathic pain. However, Nav1.8 blockers have cardiac side effects in addition to analgesic effects.
Baowen Liu +6 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 SCN10A/NaV1.8 may be associated with a lower risk of ventricular fibrillation in the setting of acute myocardial infarction (AMI), but if and by which mechanism NaV1.8 impacts on ventricular electrophysiology is still a matter of debate.
Baozhen Qi +10 more
doaj +1 more source