Results 21 to 30 of about 8,067 (198)

Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8

Frontiers in Molecular Neuroscience, 2023
Patients treated with paclitaxel (PTX) or other antineoplastic agents can experience chemotherapy-induced peripheral neuropathy (CIPN), a debilitating side effect characterized by numbness and pain.
Christopher A. Baker, Christopher A. Baker, Christopher A. Baker, Sidharth Tyagi, Sidharth Tyagi, Sidharth Tyagi, Sidharth Tyagi, Grant P. Higerd-Rusli, Grant P. Higerd-Rusli, Grant P. Higerd-Rusli, Grant P. Higerd-Rusli, Shujun Liu, Shujun Liu, Shujun Liu, Peng Zhao, Peng Zhao, Peng Zhao, Fadia B. Dib-Hajj, Fadia B. Dib-Hajj, Fadia B. Dib-Hajj, Stephen G. Waxman, Stephen G. Waxman, Stephen G. Waxman, Sulayman D. Dib-Hajj, Sulayman D. Dib-Hajj, Sulayman D. Dib-Hajj   +25 more
doaj   +1 more source

Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity

Molecular Metabolism, 2023
Objective: Obesity and nutrient oversupply increase mammalian target of rapamycin (mTOR) signaling in multiple cell types and organs, contributing to the onset of insulin resistance and complications of metabolic disease. However, it remains unclear when
Jennifer M. Brazill, David Shin, Kristann Magee, Anurag Majumdar, Ivana R. Shen, Valeria Cavalli, Erica L. Scheller   +6 more
doaj   +1 more source

The Changes in Expression of Na_V1.7 and Na_V1.8 and the Effects of the Inhalation of Their Blockers in Healthy and Ovalbumin-Sensitized Guinea Pig Airways

Membranes, 2021
Background: The presented study evaluated the suppositional changes in the airway expression of Nav1.8 and Nav1.7 and their role in the airway defense mechanisms in healthy animals and in an experimental asthma model. Methods: The effects of the blockers
Michaela Kocmalova, Ivana Kazimierova, Jana Barborikova, Marta Joskova, Sona Franova, Martina Sutovska   +5 more
doaj   +1 more source

Differential regulation of bladder pain and voiding function by sensory afferent populations revealed by selective optogenetic activation [PDF]

, 2010
Bladder-innervating primary sensory neurons mediate reflex-driven bladder function under normal conditions, and contribute to debilitating bladder pain and/or overactivity in pathological states. The goal of this study was to examine the respective roles
DeBerry, Jennifer J, Samineni, Vijay K, Copits, Bryan A, Sullivan, Christopher J, Vogt, Sherri K, Albers, Kathryn M, Davis, Brian M, Gereau, Robert W, IV   +7 more
core   +4 more sources

Mechanisms Underlying Gastrodin Alleviating Vincristine-Induced Peripheral Neuropathic Pain

Frontiers in Pharmacology, 2021
Gastrodin (GAS) is the main bioactive ingredient of Gastrodia, a famous Chinese herbal medicine widely used as an analgesic, but the underlying analgesic mechanism is still unclear.
Xiangyu Wang, Boxuan Zhang, Xuedong Li, Xuedong Li, Xingang Liu, Songsong Wang, Yuan Xie, Jialing Pi, Zhiyuan Yang, Jincan Li, Qingzhong Jia, Qingzhong Jia, Qingzhong Jia, Qingzhong Jia, Yang Zhang, Yang Zhang   +15 more
doaj   +1 more source

Suzetrigine - A Novel FDA-Approved Analgesic - Opportunities, Challenges and Future Perspectives: A Perspective Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Suzetrigine is the first class of non‐opioid analgesics that selectively targets and blocks a key mediator in pain signal transmission, NaV1.8, which is expressed in the peripheral nociceptive neurons. Suzetrigine received approval from the U.S. Food and Drug Administration (FDA) on January 30, 2025.
Mohiuddin AL, Ahmed Z.
europepmc   +2 more sources

Nav1.8 channels in ganglionated plexi modulate atrial fibrillation inducibility [PDF]

Cardiovascular Research, 2014
Emerging evidences indicate that SCN10A/NaV1.8 is associated with cardiac conduction and atrial fibrillation, but the exact role of NaV1.8 in cardiac electrophysiology remains poorly understood. The present study was designed to investigate the effects of blocking NaV1.8 channels in cardiac ganglionated plexi (GP) on modulating cardiac conduction and ...
Baozhen, Qi, Yong, Wei, Songwen, Chen, Genqing, Zhou, Hongli, Li, Juan, Xu, Yu, Ding, Xiaofeng, Lu, Liqun, Zhao, Feng, Zhang, Gang, Chen, Jing, Zhao, Shaowen, Liu   +12 more
openaire   +2 more sources

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD, Dickenson, AH, Foulkes, T, Gerke, V, Lane, T, Matthews, EA, Nassar, MA, Okuse, K, Wood, JN   +8 more
core   +1 more source

Возможная физиологическая функция эндогенного уабаина

Интегративная физиология, 2021
Наши результаты свидетельствуют о том, что эндогенный уабаин запускает два разных сигнальных процесса. Первый, быстрый процесс, приводит к модуляции активационного воротного устройства каналов NaV1.8, что снижает их функциональную активность.
Валентина Альбертовна Пеннияйнен, Вера Борисовна Плахова, Светлана Александровна Подзорова, Станислав Георгиевич Терехин, Борис Владимирович Крылов   +4 more
doaj   +1 more source

Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]

, 2006
Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Berry, Carol, Djouhri, Laiche, Fang, Xin, Dr., Lawson, Sally N., McMullan, Simon, Okuse, Kenji, Waxman, Stephen G.   +6 more
core   +1 more source